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Aberrant long-range functional connectivity density in generalized tonic-clonic seizures

Studies in generalized tonic-clonic seizures (GTCS) have reported both structural and functional alterations in the brain. However, changes in spontaneous neuronal functional organization in GTCS remain largely unknown. In this study, 70 patients with idiopathic generalized epilepsy characterized by...

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Autores principales: Zhu, Ling, Li, Yibo, Wang, Yifeng, Li, Rong, Zhang, Zhiqiang, Lu, Guangming, Chen, Huafu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998471/
https://www.ncbi.nlm.nih.gov/pubmed/27310985
http://dx.doi.org/10.1097/MD.0000000000003893
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author Zhu, Ling
Li, Yibo
Wang, Yifeng
Li, Rong
Zhang, Zhiqiang
Lu, Guangming
Chen, Huafu
author_facet Zhu, Ling
Li, Yibo
Wang, Yifeng
Li, Rong
Zhang, Zhiqiang
Lu, Guangming
Chen, Huafu
author_sort Zhu, Ling
collection PubMed
description Studies in generalized tonic-clonic seizures (GTCS) have reported both structural and functional alterations in the brain. However, changes in spontaneous neuronal functional organization in GTCS remain largely unknown. In this study, 70 patients with idiopathic generalized epilepsy characterized by tonic–clonic seizures and 70 age- and sex-matched healthy controls were recruited. Here, functional connectivity density (FCD) mapping, an ultrafast data-driven method based on functional magnetic resonance imaging (fMRI), was applied for the first time to investigate the changes of spontaneous functional brain activity caused by epilepsy. The results showed significantly decreased long-range FCD in the middle and inferior temporal, prefrontal, and inferior parietal cortices as well as increased long-range FCD in the cerebellum anterior lobe and sensorimotor areas. Negative correlation between duration of disease and reduced long-range FCD was found. In addition, most regions with reduced long-range FCD showed decreased resting-state functional connectivity (rsFC) within default mode network. Negative correlation between duration of disease and long-range FCD may reflect an adverse consequence eventually from original. Furthermore, the observed FCD and rsFC alterations have been speculated to be associated with the social–cognitive impairments as well as motor control. Our study provided novel evidences to look into neuro-pathophysiological mechanisms underlying GTCS.
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spelling pubmed-49984712016-09-02 Aberrant long-range functional connectivity density in generalized tonic-clonic seizures Zhu, Ling Li, Yibo Wang, Yifeng Li, Rong Zhang, Zhiqiang Lu, Guangming Chen, Huafu Medicine (Baltimore) 5300 Studies in generalized tonic-clonic seizures (GTCS) have reported both structural and functional alterations in the brain. However, changes in spontaneous neuronal functional organization in GTCS remain largely unknown. In this study, 70 patients with idiopathic generalized epilepsy characterized by tonic–clonic seizures and 70 age- and sex-matched healthy controls were recruited. Here, functional connectivity density (FCD) mapping, an ultrafast data-driven method based on functional magnetic resonance imaging (fMRI), was applied for the first time to investigate the changes of spontaneous functional brain activity caused by epilepsy. The results showed significantly decreased long-range FCD in the middle and inferior temporal, prefrontal, and inferior parietal cortices as well as increased long-range FCD in the cerebellum anterior lobe and sensorimotor areas. Negative correlation between duration of disease and reduced long-range FCD was found. In addition, most regions with reduced long-range FCD showed decreased resting-state functional connectivity (rsFC) within default mode network. Negative correlation between duration of disease and long-range FCD may reflect an adverse consequence eventually from original. Furthermore, the observed FCD and rsFC alterations have been speculated to be associated with the social–cognitive impairments as well as motor control. Our study provided novel evidences to look into neuro-pathophysiological mechanisms underlying GTCS. Wolters Kluwer Health 2016-06-17 /pmc/articles/PMC4998471/ /pubmed/27310985 http://dx.doi.org/10.1097/MD.0000000000003893 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 5300
Zhu, Ling
Li, Yibo
Wang, Yifeng
Li, Rong
Zhang, Zhiqiang
Lu, Guangming
Chen, Huafu
Aberrant long-range functional connectivity density in generalized tonic-clonic seizures
title Aberrant long-range functional connectivity density in generalized tonic-clonic seizures
title_full Aberrant long-range functional connectivity density in generalized tonic-clonic seizures
title_fullStr Aberrant long-range functional connectivity density in generalized tonic-clonic seizures
title_full_unstemmed Aberrant long-range functional connectivity density in generalized tonic-clonic seizures
title_short Aberrant long-range functional connectivity density in generalized tonic-clonic seizures
title_sort aberrant long-range functional connectivity density in generalized tonic-clonic seizures
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998471/
https://www.ncbi.nlm.nih.gov/pubmed/27310985
http://dx.doi.org/10.1097/MD.0000000000003893
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