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Aberrant long-range functional connectivity density in generalized tonic-clonic seizures
Studies in generalized tonic-clonic seizures (GTCS) have reported both structural and functional alterations in the brain. However, changes in spontaneous neuronal functional organization in GTCS remain largely unknown. In this study, 70 patients with idiopathic generalized epilepsy characterized by...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998471/ https://www.ncbi.nlm.nih.gov/pubmed/27310985 http://dx.doi.org/10.1097/MD.0000000000003893 |
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author | Zhu, Ling Li, Yibo Wang, Yifeng Li, Rong Zhang, Zhiqiang Lu, Guangming Chen, Huafu |
author_facet | Zhu, Ling Li, Yibo Wang, Yifeng Li, Rong Zhang, Zhiqiang Lu, Guangming Chen, Huafu |
author_sort | Zhu, Ling |
collection | PubMed |
description | Studies in generalized tonic-clonic seizures (GTCS) have reported both structural and functional alterations in the brain. However, changes in spontaneous neuronal functional organization in GTCS remain largely unknown. In this study, 70 patients with idiopathic generalized epilepsy characterized by tonic–clonic seizures and 70 age- and sex-matched healthy controls were recruited. Here, functional connectivity density (FCD) mapping, an ultrafast data-driven method based on functional magnetic resonance imaging (fMRI), was applied for the first time to investigate the changes of spontaneous functional brain activity caused by epilepsy. The results showed significantly decreased long-range FCD in the middle and inferior temporal, prefrontal, and inferior parietal cortices as well as increased long-range FCD in the cerebellum anterior lobe and sensorimotor areas. Negative correlation between duration of disease and reduced long-range FCD was found. In addition, most regions with reduced long-range FCD showed decreased resting-state functional connectivity (rsFC) within default mode network. Negative correlation between duration of disease and long-range FCD may reflect an adverse consequence eventually from original. Furthermore, the observed FCD and rsFC alterations have been speculated to be associated with the social–cognitive impairments as well as motor control. Our study provided novel evidences to look into neuro-pathophysiological mechanisms underlying GTCS. |
format | Online Article Text |
id | pubmed-4998471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49984712016-09-02 Aberrant long-range functional connectivity density in generalized tonic-clonic seizures Zhu, Ling Li, Yibo Wang, Yifeng Li, Rong Zhang, Zhiqiang Lu, Guangming Chen, Huafu Medicine (Baltimore) 5300 Studies in generalized tonic-clonic seizures (GTCS) have reported both structural and functional alterations in the brain. However, changes in spontaneous neuronal functional organization in GTCS remain largely unknown. In this study, 70 patients with idiopathic generalized epilepsy characterized by tonic–clonic seizures and 70 age- and sex-matched healthy controls were recruited. Here, functional connectivity density (FCD) mapping, an ultrafast data-driven method based on functional magnetic resonance imaging (fMRI), was applied for the first time to investigate the changes of spontaneous functional brain activity caused by epilepsy. The results showed significantly decreased long-range FCD in the middle and inferior temporal, prefrontal, and inferior parietal cortices as well as increased long-range FCD in the cerebellum anterior lobe and sensorimotor areas. Negative correlation between duration of disease and reduced long-range FCD was found. In addition, most regions with reduced long-range FCD showed decreased resting-state functional connectivity (rsFC) within default mode network. Negative correlation between duration of disease and long-range FCD may reflect an adverse consequence eventually from original. Furthermore, the observed FCD and rsFC alterations have been speculated to be associated with the social–cognitive impairments as well as motor control. Our study provided novel evidences to look into neuro-pathophysiological mechanisms underlying GTCS. Wolters Kluwer Health 2016-06-17 /pmc/articles/PMC4998471/ /pubmed/27310985 http://dx.doi.org/10.1097/MD.0000000000003893 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 5300 Zhu, Ling Li, Yibo Wang, Yifeng Li, Rong Zhang, Zhiqiang Lu, Guangming Chen, Huafu Aberrant long-range functional connectivity density in generalized tonic-clonic seizures |
title | Aberrant long-range functional connectivity density in generalized tonic-clonic seizures |
title_full | Aberrant long-range functional connectivity density in generalized tonic-clonic seizures |
title_fullStr | Aberrant long-range functional connectivity density in generalized tonic-clonic seizures |
title_full_unstemmed | Aberrant long-range functional connectivity density in generalized tonic-clonic seizures |
title_short | Aberrant long-range functional connectivity density in generalized tonic-clonic seizures |
title_sort | aberrant long-range functional connectivity density in generalized tonic-clonic seizures |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998471/ https://www.ncbi.nlm.nih.gov/pubmed/27310985 http://dx.doi.org/10.1097/MD.0000000000003893 |
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