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Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014

Strongyloides stercoralis is a soil-transmitted helminth widely diffused in tropical and subtropical regions of the world. Autochthonous cases have been also diagnosed sporadically in areas of temperate climate. We aimed at defining the epidemiology of strongyloidiasis in immigrants and Italians liv...

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Autores principales: Buonfrate, Dora, Baldissera, Mara, Abrescia, Fabrizio, Bassetti, Matteo, Caramaschi, Giacomo, Giobbia, Mario, Mascarello, Marta, Rodari, Paola, Scattolo, Novella, Napoletano, Giuseppina, Bisoffi, Zeno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998510/
https://www.ncbi.nlm.nih.gov/pubmed/27525375
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.31.30310
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author Buonfrate, Dora
Baldissera, Mara
Abrescia, Fabrizio
Bassetti, Matteo
Caramaschi, Giacomo
Giobbia, Mario
Mascarello, Marta
Rodari, Paola
Scattolo, Novella
Napoletano, Giuseppina
Bisoffi, Zeno
author_facet Buonfrate, Dora
Baldissera, Mara
Abrescia, Fabrizio
Bassetti, Matteo
Caramaschi, Giacomo
Giobbia, Mario
Mascarello, Marta
Rodari, Paola
Scattolo, Novella
Napoletano, Giuseppina
Bisoffi, Zeno
author_sort Buonfrate, Dora
collection PubMed
description Strongyloides stercoralis is a soil-transmitted helminth widely diffused in tropical and subtropical regions of the world. Autochthonous cases have been also diagnosed sporadically in areas of temperate climate. We aimed at defining the epidemiology of strongyloidiasis in immigrants and Italians living in three northern Italian Regions. Screening for S. stercoralis infection was done with serology, confirmation tests were a second serological method or stool agar culture. A case–control approach was adopted and patients with a peripheral eosinophil count ≥ 500/mcL were classified as cases. Of 2,701 individuals enrolled here 1,351 were cases and 1,350 controls; 86% were Italians, 48% women. Italians testing positive were in 8% (97/1,137) cases and 1% (13/1,178) controls (adjusted odds ratio (aOR) 8.2; 95% confidence interval (CI): 4.5–14.8), while positive immigrants were in 17% (36/214) cases and in 2% (3/172) controls (aOR 9.6; 95% CI: 2.9–32.4). Factors associated with a higher risk of infection for all study participants were eosinophilia (p < 0.001) and immigration (p = 0.001). Overall, strongyloidiasis was nine-times more frequent in individuals with eosinophilia than in those with normal eosinophil count.
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spelling pubmed-49985102016-09-28 Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014 Buonfrate, Dora Baldissera, Mara Abrescia, Fabrizio Bassetti, Matteo Caramaschi, Giacomo Giobbia, Mario Mascarello, Marta Rodari, Paola Scattolo, Novella Napoletano, Giuseppina Bisoffi, Zeno Euro Surveill Research Article Strongyloides stercoralis is a soil-transmitted helminth widely diffused in tropical and subtropical regions of the world. Autochthonous cases have been also diagnosed sporadically in areas of temperate climate. We aimed at defining the epidemiology of strongyloidiasis in immigrants and Italians living in three northern Italian Regions. Screening for S. stercoralis infection was done with serology, confirmation tests were a second serological method or stool agar culture. A case–control approach was adopted and patients with a peripheral eosinophil count ≥ 500/mcL were classified as cases. Of 2,701 individuals enrolled here 1,351 were cases and 1,350 controls; 86% were Italians, 48% women. Italians testing positive were in 8% (97/1,137) cases and 1% (13/1,178) controls (adjusted odds ratio (aOR) 8.2; 95% confidence interval (CI): 4.5–14.8), while positive immigrants were in 17% (36/214) cases and in 2% (3/172) controls (aOR 9.6; 95% CI: 2.9–32.4). Factors associated with a higher risk of infection for all study participants were eosinophilia (p < 0.001) and immigration (p = 0.001). Overall, strongyloidiasis was nine-times more frequent in individuals with eosinophilia than in those with normal eosinophil count. European Centre for Disease Prevention and Control (ECDC) 2016-08-04 /pmc/articles/PMC4998510/ /pubmed/27525375 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.31.30310 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Buonfrate, Dora
Baldissera, Mara
Abrescia, Fabrizio
Bassetti, Matteo
Caramaschi, Giacomo
Giobbia, Mario
Mascarello, Marta
Rodari, Paola
Scattolo, Novella
Napoletano, Giuseppina
Bisoffi, Zeno
Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014
title Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014
title_full Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014
title_fullStr Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014
title_full_unstemmed Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014
title_short Epidemiology of Strongyloides stercoralis in northern Italy: results of a multicentre case–control study, February 2013 to July 2014
title_sort epidemiology of strongyloides stercoralis in northern italy: results of a multicentre case–control study, february 2013 to july 2014
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998510/
https://www.ncbi.nlm.nih.gov/pubmed/27525375
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.31.30310
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