Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates

Despite recent technological advances in quantifying antibody drug conjugate (ADC) species, such as total antibody, conjugated antibody, conjugated drug, and payload drug in circulation, the correlation of their exposures with the efficacy of ADC outcomes in vivo remains challenging. Here, the chemi...

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Detalles Bibliográficos
Autores principales: Zhang, Donglu, Yu, Shang-Fan, Ma, Yong, Xu, Keyang, Dragovich, Peter S., Pillow, Thomas H., Liu, Luna, Del Rosario, Geoffrey, He, Jintang, Pei, Zhonghua, Sadowsky, Jack D., Erickson, Hans K., Hop, Cornelis E. C. A., Khojasteh, S. Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998580/
https://www.ncbi.nlm.nih.gov/pubmed/27417182
http://dx.doi.org/10.1124/dmd.116.070631

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