Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (h...

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Detalles Bibliográficos
Autores principales: Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Drug Discovery and Translational Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998676/
https://www.ncbi.nlm.nih.gov/pubmed/27411717
http://dx.doi.org/10.1124/jpet.116.235333

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