Cargando…
The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies
Previous studies suggested that diabetes mellitus (DM) was associated with risk and mortality of cancer, but studies investigating the correlation between DM and lung cancer prognosis remain controversial. Herein, a meta-analysis was performed to derive a more precise estimate of the prognostic role...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998725/ https://www.ncbi.nlm.nih.gov/pubmed/27124062 http://dx.doi.org/10.1097/MD.0000000000003528 |
_version_ | 1782449993910583296 |
---|---|
author | Zhu, Linhai Cao, Hongxin Zhang, Tiehong Shen, Hongchang Dong, Wei Wang, Liguang Du, Jiajun |
author_facet | Zhu, Linhai Cao, Hongxin Zhang, Tiehong Shen, Hongchang Dong, Wei Wang, Liguang Du, Jiajun |
author_sort | Zhu, Linhai |
collection | PubMed |
description | Previous studies suggested that diabetes mellitus (DM) was associated with risk and mortality of cancer, but studies investigating the correlation between DM and lung cancer prognosis remain controversial. Herein, a meta-analysis was performed to derive a more precise estimate of the prognostic role of DM in lung cancer. Medline and Embase were searched for eligible articles from inception to October 25, 2015. The pooled hazard ratio (HR) with its 95% confidence interval (95% CI) was calculated to evaluate the correlation between DM and lung cancer prognosis. Subgroup meta-analysis was performed based on the histology and the treatment methods. A total of 20 cohort studies from 12 articles were included in the meta-analysis. Also, 16 studies investigated the overall survival (OS) and 4 studies investigated the progression-free survival (PFS). DM was significantly associated with the inferior OS of lung cancer with the pooled HR 1.28 (95% CI: 1.10–1.49, P = 0.001). The association was prominent in the nonsmall cell lung cancer (NSCLC) subgroup (HR 1.35, 95%CI: 1.14–1.60, P = 0.002), whereas the association was not significant in the small cell lung cancer (SCLC) subgroup (HR 1.33, 95% CI: 0.87–2.03, P = 0.18). When NSCLC patients were further stratified by treatment methods, DM had more influence on the surgically treated subgroup than the nonsurgically treated subgroup. There was no obvious evidence for publication bias by Begg's and Egger's test. The results of this meta-analysis exhibit an association of DM with inferior prognosis amongst lung cancer patients, especially the surgically treated NSCLC patients. Given the small number of studies included in this meta-analysis, the present conclusion should be consolidated with more high-quality prospective cohort studies or randomized controlled trials. |
format | Online Article Text |
id | pubmed-4998725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49987252016-09-06 The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies Zhu, Linhai Cao, Hongxin Zhang, Tiehong Shen, Hongchang Dong, Wei Wang, Liguang Du, Jiajun Medicine (Baltimore) 5700 Previous studies suggested that diabetes mellitus (DM) was associated with risk and mortality of cancer, but studies investigating the correlation between DM and lung cancer prognosis remain controversial. Herein, a meta-analysis was performed to derive a more precise estimate of the prognostic role of DM in lung cancer. Medline and Embase were searched for eligible articles from inception to October 25, 2015. The pooled hazard ratio (HR) with its 95% confidence interval (95% CI) was calculated to evaluate the correlation between DM and lung cancer prognosis. Subgroup meta-analysis was performed based on the histology and the treatment methods. A total of 20 cohort studies from 12 articles were included in the meta-analysis. Also, 16 studies investigated the overall survival (OS) and 4 studies investigated the progression-free survival (PFS). DM was significantly associated with the inferior OS of lung cancer with the pooled HR 1.28 (95% CI: 1.10–1.49, P = 0.001). The association was prominent in the nonsmall cell lung cancer (NSCLC) subgroup (HR 1.35, 95%CI: 1.14–1.60, P = 0.002), whereas the association was not significant in the small cell lung cancer (SCLC) subgroup (HR 1.33, 95% CI: 0.87–2.03, P = 0.18). When NSCLC patients were further stratified by treatment methods, DM had more influence on the surgically treated subgroup than the nonsurgically treated subgroup. There was no obvious evidence for publication bias by Begg's and Egger's test. The results of this meta-analysis exhibit an association of DM with inferior prognosis amongst lung cancer patients, especially the surgically treated NSCLC patients. Given the small number of studies included in this meta-analysis, the present conclusion should be consolidated with more high-quality prospective cohort studies or randomized controlled trials. Wolters Kluwer Health 2016-04-29 /pmc/articles/PMC4998725/ /pubmed/27124062 http://dx.doi.org/10.1097/MD.0000000000003528 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5700 Zhu, Linhai Cao, Hongxin Zhang, Tiehong Shen, Hongchang Dong, Wei Wang, Liguang Du, Jiajun The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies |
title | The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies |
title_full | The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies |
title_fullStr | The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies |
title_full_unstemmed | The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies |
title_short | The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies |
title_sort | effect of diabetes mellitus on lung cancer prognosis: a prisma-compliant meta-analysis of cohort studies |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998725/ https://www.ncbi.nlm.nih.gov/pubmed/27124062 http://dx.doi.org/10.1097/MD.0000000000003528 |
work_keys_str_mv | AT zhulinhai theeffectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT caohongxin theeffectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT zhangtiehong theeffectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT shenhongchang theeffectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT dongwei theeffectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT wangliguang theeffectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT dujiajun theeffectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT zhulinhai effectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT caohongxin effectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT zhangtiehong effectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT shenhongchang effectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT dongwei effectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT wangliguang effectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies AT dujiajun effectofdiabetesmellitusonlungcancerprognosisaprismacompliantmetaanalysisofcohortstudies |