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Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan

We aimed to investigate the clinical characteristics of patients with herpes esophagitis (HE) based on endoscopic typing. Herpes simplex virus infection in the gastrointestinal tract primarily affects the esophagus. However, little is known about the presentation, endoscopic findings, and outcomes o...

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Autores principales: Wang, Hung-Wei, Kuo, Chia-Jung, Lin, Wey-Ran, Hsu, Chen-Ming, Ho, Yu-Pin, Lin, Chun-Jung, Su, Ming-Yao, Chiu, Cheng-Tang, Chen, Kuang-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998761/
https://www.ncbi.nlm.nih.gov/pubmed/27057845
http://dx.doi.org/10.1097/MD.0000000000003187
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author Wang, Hung-Wei
Kuo, Chia-Jung
Lin, Wey-Ran
Hsu, Chen-Ming
Ho, Yu-Pin
Lin, Chun-Jung
Su, Ming-Yao
Chiu, Cheng-Tang
Chen, Kuang-Hua
author_facet Wang, Hung-Wei
Kuo, Chia-Jung
Lin, Wey-Ran
Hsu, Chen-Ming
Ho, Yu-Pin
Lin, Chun-Jung
Su, Ming-Yao
Chiu, Cheng-Tang
Chen, Kuang-Hua
author_sort Wang, Hung-Wei
collection PubMed
description We aimed to investigate the clinical characteristics of patients with herpes esophagitis (HE) based on endoscopic typing. Herpes simplex virus infection in the gastrointestinal tract primarily affects the esophagus. However, little is known about the presentation, endoscopic findings, and outcomes of HE. From 2003 to 2013, 47 patients with HE were identified histologically from among 1843 patients with esophageal ulcers. Personal data, underlying disease, esophagogastroduodenoscopy indication, endoscopic characteristics, pathological findings, laboratory data, and outcomes were collected. Endoscopic findings were classified into 3 types based on gross appearance and were correlated with clinical presentation. The mean age of patients was 62.04 ± 14.76 years, and most patients were men (39/47, 83%). The most common symptoms were odynophagia/dysphagia (20/47, 42.6%). Whereas 25 patients (53.2%) were diagnosed with malignancy, it was related to human immunodeficiency virus in only 1 patient (2.1%). HE was classified into 3 types based on endoscopic images: type I (n = 19), type II (n = 10), and type III (n = 18). The majority of patients with HE type III had sepsis (72%) and obvious leukocytosis than the other 2 types (P = 0.03). The overall mortality rate was 6.4% (3/47), and most of the patients who died (66.7% [2/3]) belonged to the endoscopic classification type III group. Clinical parameters were analyzed for the risk of poor outcome. Postchemotherapy and/or radiotherapy were associated with 30-day mortality after appearance of HE (P < 0.05). Herpes esophagitis primarily affects men and patients with malignancy or sepsis. However, the disease is usually self-limiting, and HE-related mortality is low. Relationship between severity of endoscopic findings and patients’ outcome remains questionable. Further prospective study is needed.
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spelling pubmed-49987612016-08-29 Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan Wang, Hung-Wei Kuo, Chia-Jung Lin, Wey-Ran Hsu, Chen-Ming Ho, Yu-Pin Lin, Chun-Jung Su, Ming-Yao Chiu, Cheng-Tang Chen, Kuang-Hua Medicine (Baltimore) 4500 We aimed to investigate the clinical characteristics of patients with herpes esophagitis (HE) based on endoscopic typing. Herpes simplex virus infection in the gastrointestinal tract primarily affects the esophagus. However, little is known about the presentation, endoscopic findings, and outcomes of HE. From 2003 to 2013, 47 patients with HE were identified histologically from among 1843 patients with esophageal ulcers. Personal data, underlying disease, esophagogastroduodenoscopy indication, endoscopic characteristics, pathological findings, laboratory data, and outcomes were collected. Endoscopic findings were classified into 3 types based on gross appearance and were correlated with clinical presentation. The mean age of patients was 62.04 ± 14.76 years, and most patients were men (39/47, 83%). The most common symptoms were odynophagia/dysphagia (20/47, 42.6%). Whereas 25 patients (53.2%) were diagnosed with malignancy, it was related to human immunodeficiency virus in only 1 patient (2.1%). HE was classified into 3 types based on endoscopic images: type I (n = 19), type II (n = 10), and type III (n = 18). The majority of patients with HE type III had sepsis (72%) and obvious leukocytosis than the other 2 types (P = 0.03). The overall mortality rate was 6.4% (3/47), and most of the patients who died (66.7% [2/3]) belonged to the endoscopic classification type III group. Clinical parameters were analyzed for the risk of poor outcome. Postchemotherapy and/or radiotherapy were associated with 30-day mortality after appearance of HE (P < 0.05). Herpes esophagitis primarily affects men and patients with malignancy or sepsis. However, the disease is usually self-limiting, and HE-related mortality is low. Relationship between severity of endoscopic findings and patients’ outcome remains questionable. Further prospective study is needed. Wolters Kluwer Health 2016-04-08 /pmc/articles/PMC4998761/ /pubmed/27057845 http://dx.doi.org/10.1097/MD.0000000000003187 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 4500
Wang, Hung-Wei
Kuo, Chia-Jung
Lin, Wey-Ran
Hsu, Chen-Ming
Ho, Yu-Pin
Lin, Chun-Jung
Su, Ming-Yao
Chiu, Cheng-Tang
Chen, Kuang-Hua
Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan
title Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan
title_full Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan
title_fullStr Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan
title_full_unstemmed Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan
title_short Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan
title_sort clinical characteristics and manifestation of herpes esophagitis: one single-center experience in taiwan
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998761/
https://www.ncbi.nlm.nih.gov/pubmed/27057845
http://dx.doi.org/10.1097/MD.0000000000003187
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