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Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD

It is shown that there are strong associations between nonalcoholic fatty liver disease (NAFLD) and endothelial dysfunction. The aim of our study was to reveal whether steatosis or fibrosis score is more important in the development of endothelial dysfunction in patients with NAFLD in a prospective...

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Autores principales: Sapmaz, Ferdane, Uzman, Metin, Basyigit, Sebahat, Ozkan, Selcuk, Yavuz, Bunyamin, Yeniova, Abdullah, Kefeli, Ayse, Asilturk, Zeliha, Nazligül, Yasar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998806/
https://www.ncbi.nlm.nih.gov/pubmed/27057890
http://dx.doi.org/10.1097/MD.0000000000003280
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author Sapmaz, Ferdane
Uzman, Metin
Basyigit, Sebahat
Ozkan, Selcuk
Yavuz, Bunyamin
Yeniova, Abdullah
Kefeli, Ayse
Asilturk, Zeliha
Nazligül, Yasar
author_facet Sapmaz, Ferdane
Uzman, Metin
Basyigit, Sebahat
Ozkan, Selcuk
Yavuz, Bunyamin
Yeniova, Abdullah
Kefeli, Ayse
Asilturk, Zeliha
Nazligül, Yasar
author_sort Sapmaz, Ferdane
collection PubMed
description It is shown that there are strong associations between nonalcoholic fatty liver disease (NAFLD) and endothelial dysfunction. The aim of our study was to reveal whether steatosis or fibrosis score is more important in the development of endothelial dysfunction in patients with NAFLD in a prospective manner. This cross-sectional study included 266 subjects. These subjects were divided into 2 groups depending on presence of hepatosteatosis sonographically. Patients with hepatosteatosis were also divided into 3 subgroups depending on degree of steatosis: grade 1, 2, and 3. In all patients, Aspartate aminotransferase-to-Platelet Ratio Index and Fibrosis-4 (FIB4) scores were calculated. In addition, flow-mediated dilatation (FMD) measurements were recorded. There was NAFLD in 176 (66.2%) of 266 patients included. There were no significant differences in sex and age distributions between patients with NAFLD (group 1) and controls without NAFLD (group 2) (P = 0.05). Mean Aspartate aminotransferase-to-Platelet Ratio Index score was significantly higher in group 1 compared with the control group (P = 0.001), whereas no significant difference was detected regarding FIB4 scores between groups (P = 0.4). Mean FMD value was found to be significantly lower in group 1 (P = 0.008). Patients with grade 3 hepatosteatosis had significantly lower FMD values than those with grade 1 steatosis and controls (P = 0.001). In univariate and multivariate analyses in group 1, no significant difference was detected regarding mean FMD measurements (P = 0.03). Again, no significant difference was detected in mean FMD measurement between FIB4 subgroups among patients with NAFLD and the whole study group (P = 0.09). The endothelial dysfunction is associated with steatosis in patients with NAFLD.
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spelling pubmed-49988062016-08-29 Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD Sapmaz, Ferdane Uzman, Metin Basyigit, Sebahat Ozkan, Selcuk Yavuz, Bunyamin Yeniova, Abdullah Kefeli, Ayse Asilturk, Zeliha Nazligül, Yasar Medicine (Baltimore) 4500 It is shown that there are strong associations between nonalcoholic fatty liver disease (NAFLD) and endothelial dysfunction. The aim of our study was to reveal whether steatosis or fibrosis score is more important in the development of endothelial dysfunction in patients with NAFLD in a prospective manner. This cross-sectional study included 266 subjects. These subjects were divided into 2 groups depending on presence of hepatosteatosis sonographically. Patients with hepatosteatosis were also divided into 3 subgroups depending on degree of steatosis: grade 1, 2, and 3. In all patients, Aspartate aminotransferase-to-Platelet Ratio Index and Fibrosis-4 (FIB4) scores were calculated. In addition, flow-mediated dilatation (FMD) measurements were recorded. There was NAFLD in 176 (66.2%) of 266 patients included. There were no significant differences in sex and age distributions between patients with NAFLD (group 1) and controls without NAFLD (group 2) (P = 0.05). Mean Aspartate aminotransferase-to-Platelet Ratio Index score was significantly higher in group 1 compared with the control group (P = 0.001), whereas no significant difference was detected regarding FIB4 scores between groups (P = 0.4). Mean FMD value was found to be significantly lower in group 1 (P = 0.008). Patients with grade 3 hepatosteatosis had significantly lower FMD values than those with grade 1 steatosis and controls (P = 0.001). In univariate and multivariate analyses in group 1, no significant difference was detected regarding mean FMD measurements (P = 0.03). Again, no significant difference was detected in mean FMD measurement between FIB4 subgroups among patients with NAFLD and the whole study group (P = 0.09). The endothelial dysfunction is associated with steatosis in patients with NAFLD. Wolters Kluwer Health 2016-04-08 /pmc/articles/PMC4998806/ /pubmed/27057890 http://dx.doi.org/10.1097/MD.0000000000003280 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4500
Sapmaz, Ferdane
Uzman, Metin
Basyigit, Sebahat
Ozkan, Selcuk
Yavuz, Bunyamin
Yeniova, Abdullah
Kefeli, Ayse
Asilturk, Zeliha
Nazligül, Yasar
Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD
title Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD
title_full Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD
title_fullStr Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD
title_full_unstemmed Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD
title_short Steatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD
title_sort steatosis grade is the most important risk factor for development of endothelial dysfunction in nafld
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998806/
https://www.ncbi.nlm.nih.gov/pubmed/27057890
http://dx.doi.org/10.1097/MD.0000000000003280
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