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Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis

The aim of the study was to examine how well aggregate data meta-analyses (ADMAs) and individual patient data meta-analyses (IPDMAs) agree in their overall results and how frequently interactions are detected in IPDMAs and ADMAs. ADMA articles immediately published before the IPDMA and matching the...

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Autores principales: Huang, Yafang, Tang, Jinling, Tam, Wilson Wai-san, Mao, Chen, Yuan, Jinqiu, Di, Mengyang, Yang, Zuyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998822/
https://www.ncbi.nlm.nih.gov/pubmed/27057906
http://dx.doi.org/10.1097/MD.0000000000003312
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author Huang, Yafang
Tang, Jinling
Tam, Wilson Wai-san
Mao, Chen
Yuan, Jinqiu
Di, Mengyang
Yang, Zuyao
author_facet Huang, Yafang
Tang, Jinling
Tam, Wilson Wai-san
Mao, Chen
Yuan, Jinqiu
Di, Mengyang
Yang, Zuyao
author_sort Huang, Yafang
collection PubMed
description The aim of the study was to examine how well aggregate data meta-analyses (ADMAs) and individual patient data meta-analyses (IPDMAs) agree in their overall results and how frequently interactions are detected in IPDMAs and ADMAs. ADMA articles immediately published before the IPDMA and matching the research topic were identified. Agreement in the overall result was achieved if the estimate was in the same direction. The number of subgroup analyses, in particular that of significant interactions, was compared between the 2 types of meta-analyses. A total of 829 IPDMA articles were identified; 129 (15.6%) were found to have a matched ADMA article and 204 paired meta-analyses were identified. Agreement in the overall effect was observed in 187 (91.7%) of the 204 paired meta-analyses. Fifty-three (26.0%) ADMAs and 121 (59.3%) IPDMAs conducted subgroup analyses and presented 150 and 634 subgroup analyses, respectively. The IPDMAs conducted 7 times more subgroup analyses on interaction (544 in IPDMAs vs 68 in ADMAs) and identified 14 times more potential interactions (44 in IPDMAs vs 3 in ADMAs). ADMAs will almost always agree with their corresponding IPDMAs in the overall result if greater efforts are made to improve the methodology in conducting ADMAs. The IPDMA is required mostly if interactions are suspected.
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spelling pubmed-49988222016-08-29 Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis Huang, Yafang Tang, Jinling Tam, Wilson Wai-san Mao, Chen Yuan, Jinqiu Di, Mengyang Yang, Zuyao Medicine (Baltimore) 4400 The aim of the study was to examine how well aggregate data meta-analyses (ADMAs) and individual patient data meta-analyses (IPDMAs) agree in their overall results and how frequently interactions are detected in IPDMAs and ADMAs. ADMA articles immediately published before the IPDMA and matching the research topic were identified. Agreement in the overall result was achieved if the estimate was in the same direction. The number of subgroup analyses, in particular that of significant interactions, was compared between the 2 types of meta-analyses. A total of 829 IPDMA articles were identified; 129 (15.6%) were found to have a matched ADMA article and 204 paired meta-analyses were identified. Agreement in the overall effect was observed in 187 (91.7%) of the 204 paired meta-analyses. Fifty-three (26.0%) ADMAs and 121 (59.3%) IPDMAs conducted subgroup analyses and presented 150 and 634 subgroup analyses, respectively. The IPDMAs conducted 7 times more subgroup analyses on interaction (544 in IPDMAs vs 68 in ADMAs) and identified 14 times more potential interactions (44 in IPDMAs vs 3 in ADMAs). ADMAs will almost always agree with their corresponding IPDMAs in the overall result if greater efforts are made to improve the methodology in conducting ADMAs. The IPDMA is required mostly if interactions are suspected. Wolters Kluwer Health 2016-04-08 /pmc/articles/PMC4998822/ /pubmed/27057906 http://dx.doi.org/10.1097/MD.0000000000003312 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4400
Huang, Yafang
Tang, Jinling
Tam, Wilson Wai-san
Mao, Chen
Yuan, Jinqiu
Di, Mengyang
Yang, Zuyao
Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis
title Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis
title_full Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis
title_fullStr Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis
title_full_unstemmed Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis
title_short Comparing the Overall Result and Interaction in Aggregate Data Meta-Analysis and Individual Patient Data Meta-Analysis
title_sort comparing the overall result and interaction in aggregate data meta-analysis and individual patient data meta-analysis
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998822/
https://www.ncbi.nlm.nih.gov/pubmed/27057906
http://dx.doi.org/10.1097/MD.0000000000003312
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