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High Mortality of Cirrhotic Patients With End-Stage Renal Disease
Ascites, hepatic encephalopathy (HE), and esophageal variceal bleeding (EVB) are 3 major complications in patients with cirrhosis. Limited data exist with which to evaluate the long-term mortality of end-stage renal disease (ESRD) in cirrhotic patients with or without complications. The National Hea...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998915/ https://www.ncbi.nlm.nih.gov/pubmed/26962834 http://dx.doi.org/10.1097/MD.0000000000003057 |
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author | Hung, Tsung-Hsing Tsai, Chen-Chi Tseng, Kuo-Chih Tseng, Chih -Wei Hsieh, Yu-Hsi Tsai, Chih-Chun Lee, Hsing-Feng |
author_facet | Hung, Tsung-Hsing Tsai, Chen-Chi Tseng, Kuo-Chih Tseng, Chih -Wei Hsieh, Yu-Hsi Tsai, Chih-Chun Lee, Hsing-Feng |
author_sort | Hung, Tsung-Hsing |
collection | PubMed |
description | Ascites, hepatic encephalopathy (HE), and esophageal variceal bleeding (EVB) are 3 major complications in patients with cirrhosis. Limited data exist with which to evaluate the long-term mortality of end-stage renal disease (ESRD) in cirrhotic patients with or without complications. The National Health Insurance Database in Taiwan was used to identify patients with cirrhosis hospitalized between January 1, 2007, and December 31, 2007. The study group consisted of 1068 cirrhotic patients with ESRD, and the control group consisted of 10,680 randomly selected cirrhotic patients without baseline renal function impairment. The overall 1-year and 3-year mortality rates were 48.5% and 73.1% in the ESRD group, and 32.9% and 55.6% in the control group, respectively. After adjusting for other comorbid disorders, the cirrhotic patients with ESRD showed a statistically significant increase in 3-year mortality (hazard ratio [HR], 1.65; P < 0.001). The HR for 3-year mortality of ESRD cirrhotic patients with recurrent complications was 1.98 (P < 0.001), compared to those with no recent or past complications. The HR of ESRD for 3-year mortality was 1.48 (P < 0.001) in cirrhotic patients with ascites, 1.67 (P < 0.001) in patients with EVB, and 1.19 (P = 0.147) in patients with HE. ESRD increases the mortality rate in patients with cirrhosis. Recurrent complications can account for a 2-fold increase in the 3-year mortality of ESRD cirrhotic patients. ESRD has a smaller impact on the 3-year mortality of cirrhotic patients with HE compared to those with ascites or EVB. |
format | Online Article Text |
id | pubmed-4998915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49989152016-08-29 High Mortality of Cirrhotic Patients With End-Stage Renal Disease Hung, Tsung-Hsing Tsai, Chen-Chi Tseng, Kuo-Chih Tseng, Chih -Wei Hsieh, Yu-Hsi Tsai, Chih-Chun Lee, Hsing-Feng Medicine (Baltimore) 4500 Ascites, hepatic encephalopathy (HE), and esophageal variceal bleeding (EVB) are 3 major complications in patients with cirrhosis. Limited data exist with which to evaluate the long-term mortality of end-stage renal disease (ESRD) in cirrhotic patients with or without complications. The National Health Insurance Database in Taiwan was used to identify patients with cirrhosis hospitalized between January 1, 2007, and December 31, 2007. The study group consisted of 1068 cirrhotic patients with ESRD, and the control group consisted of 10,680 randomly selected cirrhotic patients without baseline renal function impairment. The overall 1-year and 3-year mortality rates were 48.5% and 73.1% in the ESRD group, and 32.9% and 55.6% in the control group, respectively. After adjusting for other comorbid disorders, the cirrhotic patients with ESRD showed a statistically significant increase in 3-year mortality (hazard ratio [HR], 1.65; P < 0.001). The HR for 3-year mortality of ESRD cirrhotic patients with recurrent complications was 1.98 (P < 0.001), compared to those with no recent or past complications. The HR of ESRD for 3-year mortality was 1.48 (P < 0.001) in cirrhotic patients with ascites, 1.67 (P < 0.001) in patients with EVB, and 1.19 (P = 0.147) in patients with HE. ESRD increases the mortality rate in patients with cirrhosis. Recurrent complications can account for a 2-fold increase in the 3-year mortality of ESRD cirrhotic patients. ESRD has a smaller impact on the 3-year mortality of cirrhotic patients with HE compared to those with ascites or EVB. Wolters Kluwer Health 2016-03-11 /pmc/articles/PMC4998915/ /pubmed/26962834 http://dx.doi.org/10.1097/MD.0000000000003057 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 4500 Hung, Tsung-Hsing Tsai, Chen-Chi Tseng, Kuo-Chih Tseng, Chih -Wei Hsieh, Yu-Hsi Tsai, Chih-Chun Lee, Hsing-Feng High Mortality of Cirrhotic Patients With End-Stage Renal Disease |
title | High Mortality of Cirrhotic Patients With End-Stage Renal Disease |
title_full | High Mortality of Cirrhotic Patients With End-Stage Renal Disease |
title_fullStr | High Mortality of Cirrhotic Patients With End-Stage Renal Disease |
title_full_unstemmed | High Mortality of Cirrhotic Patients With End-Stage Renal Disease |
title_short | High Mortality of Cirrhotic Patients With End-Stage Renal Disease |
title_sort | high mortality of cirrhotic patients with end-stage renal disease |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998915/ https://www.ncbi.nlm.nih.gov/pubmed/26962834 http://dx.doi.org/10.1097/MD.0000000000003057 |
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