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Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
BACKGROUND: Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL/METHODS: The genotyping of PTX3 polymorphisms in 101 AS patients and 93 con...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999015/ https://www.ncbi.nlm.nih.gov/pubmed/27538101 http://dx.doi.org/10.12659/MSM.896562 |
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author | Zhang, Xu Ding, Wenyuan |
author_facet | Zhang, Xu Ding, Wenyuan |
author_sort | Zhang, Xu |
collection | PubMed |
description | BACKGROUND: Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL/METHODS: The genotyping of PTX3 polymorphisms in 101 AS patients and 93 controls was conducted by allelic discrimination assay and the genotype distribution was assessed for Hardy-Weinberg equilibrium (HWE). The differences of genotype, allele, haplotype, and some basic indexes were compared by χ(2) test. Odds ratio (OR) and 95% confidence interval (95%CI) were also calculated by χ(2) test and were used to evaluate the association intensity between gene polymorphisms and disease. Haploview software was used to analyze the linkage disequilibrium (LD) and haplotypes of PTX3 polymorphisms. RESULTS: CC genotype of rs3816527 had an obviously higher frequency in cases than in controls and had a positive effect on AS occurrence (OR=3.14, 95%CI=1.04–9.52), and the same was true of the C allele in rs3816527. For rs3845978, CT genotype showed a significant frequency difference between the case and control groups (P=0.03) and people with genotypes carrying the T allele developed AS earlier (OR=1.94, 95%CI=1.09–3.47), and the same was found in the analysis of the T allele. G-C-T haplotype dramatically increased the risk of AS, as may A-C-C haplotype. CONCLUSIONS: In PTX3 polymorphisms rs3816527 and rs3845978 were found to be associated with AS, but rs2305619 was not. |
format | Online Article Text |
id | pubmed-4999015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49990152016-09-07 Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis Zhang, Xu Ding, Wenyuan Med Sci Monit Molecular Biology BACKGROUND: Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL/METHODS: The genotyping of PTX3 polymorphisms in 101 AS patients and 93 controls was conducted by allelic discrimination assay and the genotype distribution was assessed for Hardy-Weinberg equilibrium (HWE). The differences of genotype, allele, haplotype, and some basic indexes were compared by χ(2) test. Odds ratio (OR) and 95% confidence interval (95%CI) were also calculated by χ(2) test and were used to evaluate the association intensity between gene polymorphisms and disease. Haploview software was used to analyze the linkage disequilibrium (LD) and haplotypes of PTX3 polymorphisms. RESULTS: CC genotype of rs3816527 had an obviously higher frequency in cases than in controls and had a positive effect on AS occurrence (OR=3.14, 95%CI=1.04–9.52), and the same was true of the C allele in rs3816527. For rs3845978, CT genotype showed a significant frequency difference between the case and control groups (P=0.03) and people with genotypes carrying the T allele developed AS earlier (OR=1.94, 95%CI=1.09–3.47), and the same was found in the analysis of the T allele. G-C-T haplotype dramatically increased the risk of AS, as may A-C-C haplotype. CONCLUSIONS: In PTX3 polymorphisms rs3816527 and rs3845978 were found to be associated with AS, but rs2305619 was not. International Scientific Literature, Inc. 2016-08-18 /pmc/articles/PMC4999015/ /pubmed/27538101 http://dx.doi.org/10.12659/MSM.896562 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
spellingShingle | Molecular Biology Zhang, Xu Ding, Wenyuan Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis |
title | Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis |
title_full | Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis |
title_fullStr | Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis |
title_full_unstemmed | Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis |
title_short | Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis |
title_sort | association of genetic variants in pentraxin 3 gene with ankylosing spondylitis |
topic | Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999015/ https://www.ncbi.nlm.nih.gov/pubmed/27538101 http://dx.doi.org/10.12659/MSM.896562 |
work_keys_str_mv | AT zhangxu associationofgeneticvariantsinpentraxin3genewithankylosingspondylitis AT dingwenyuan associationofgeneticvariantsinpentraxin3genewithankylosingspondylitis |