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Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis

BACKGROUND: Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL/METHODS: The genotyping of PTX3 polymorphisms in 101 AS patients and 93 con...

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Autores principales: Zhang, Xu, Ding, Wenyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999015/
https://www.ncbi.nlm.nih.gov/pubmed/27538101
http://dx.doi.org/10.12659/MSM.896562
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author Zhang, Xu
Ding, Wenyuan
author_facet Zhang, Xu
Ding, Wenyuan
author_sort Zhang, Xu
collection PubMed
description BACKGROUND: Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL/METHODS: The genotyping of PTX3 polymorphisms in 101 AS patients and 93 controls was conducted by allelic discrimination assay and the genotype distribution was assessed for Hardy-Weinberg equilibrium (HWE). The differences of genotype, allele, haplotype, and some basic indexes were compared by χ(2) test. Odds ratio (OR) and 95% confidence interval (95%CI) were also calculated by χ(2) test and were used to evaluate the association intensity between gene polymorphisms and disease. Haploview software was used to analyze the linkage disequilibrium (LD) and haplotypes of PTX3 polymorphisms. RESULTS: CC genotype of rs3816527 had an obviously higher frequency in cases than in controls and had a positive effect on AS occurrence (OR=3.14, 95%CI=1.04–9.52), and the same was true of the C allele in rs3816527. For rs3845978, CT genotype showed a significant frequency difference between the case and control groups (P=0.03) and people with genotypes carrying the T allele developed AS earlier (OR=1.94, 95%CI=1.09–3.47), and the same was found in the analysis of the T allele. G-C-T haplotype dramatically increased the risk of AS, as may A-C-C haplotype. CONCLUSIONS: In PTX3 polymorphisms rs3816527 and rs3845978 were found to be associated with AS, but rs2305619 was not.
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spelling pubmed-49990152016-09-07 Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis Zhang, Xu Ding, Wenyuan Med Sci Monit Molecular Biology BACKGROUND: Pentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk. MATERIAL/METHODS: The genotyping of PTX3 polymorphisms in 101 AS patients and 93 controls was conducted by allelic discrimination assay and the genotype distribution was assessed for Hardy-Weinberg equilibrium (HWE). The differences of genotype, allele, haplotype, and some basic indexes were compared by χ(2) test. Odds ratio (OR) and 95% confidence interval (95%CI) were also calculated by χ(2) test and were used to evaluate the association intensity between gene polymorphisms and disease. Haploview software was used to analyze the linkage disequilibrium (LD) and haplotypes of PTX3 polymorphisms. RESULTS: CC genotype of rs3816527 had an obviously higher frequency in cases than in controls and had a positive effect on AS occurrence (OR=3.14, 95%CI=1.04–9.52), and the same was true of the C allele in rs3816527. For rs3845978, CT genotype showed a significant frequency difference between the case and control groups (P=0.03) and people with genotypes carrying the T allele developed AS earlier (OR=1.94, 95%CI=1.09–3.47), and the same was found in the analysis of the T allele. G-C-T haplotype dramatically increased the risk of AS, as may A-C-C haplotype. CONCLUSIONS: In PTX3 polymorphisms rs3816527 and rs3845978 were found to be associated with AS, but rs2305619 was not. International Scientific Literature, Inc. 2016-08-18 /pmc/articles/PMC4999015/ /pubmed/27538101 http://dx.doi.org/10.12659/MSM.896562 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Molecular Biology
Zhang, Xu
Ding, Wenyuan
Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
title Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
title_full Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
title_fullStr Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
title_full_unstemmed Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
title_short Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis
title_sort association of genetic variants in pentraxin 3 gene with ankylosing spondylitis
topic Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999015/
https://www.ncbi.nlm.nih.gov/pubmed/27538101
http://dx.doi.org/10.12659/MSM.896562
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