CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment

BACKGROUND: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface antigen on several immune cells. It has been suggested that lymphocyte depletion increases the risk...

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Detalles Bibliográficos
Autores principales: Hotta, Ryuichi, Ohira, Masahiro, Matsuura, Toshiharu, Muraoka, Izumi, Tryphonopoulos, Panagiotis, Fan, Ji, Tekin, Akin, Selvaggi, Gennaro, Levi, David, Ruiz, Phillip, Ricordi, Camillo, Vianna, Rodrigo, Ohdan, Hideki, Waldmann, Herman, Tzakis, Andreas G., Nishida, Seigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999148/
https://www.ncbi.nlm.nih.gov/pubmed/27560943
http://dx.doi.org/10.1371/journal.pone.0161618

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