Cargando…
Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression
The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-last...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999190/ https://www.ncbi.nlm.nih.gov/pubmed/27560350 http://dx.doi.org/10.1371/journal.pone.0161679 |
_version_ | 1782450077706485760 |
---|---|
author | Li, Yinyun Kulvicius, Tomas Tetzlaff, Christian |
author_facet | Li, Yinyun Kulvicius, Tomas Tetzlaff, Christian |
author_sort | Li, Yinyun |
collection | PubMed |
description | The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-lasting late-phase state. The underlying processes of this synaptic consolidation are already well-known for homosynaptic plasticity, however, it is not clear whether the same processes also enable the induction and consolidation of heterosynaptic plasticity. In this study, by extending a generic calcium-based plasticity model with the processes of synaptic consolidation, we show in simulations that indeed heterosynaptic plasticity can be induced and, furthermore, consolidated by the same underlying processes as for homosynaptic plasticity. Furthermore, we show that by local diffusion processes the heterosynaptic effect can be restricted to a few synapses neighboring the homosynaptically changed ones. Taken together, this generic model reproduces many experimental results of synaptic tagging and consolidation, provides several predictions for heterosynaptic induction and consolidation, and yields insights into the complex interactions between homo- and heterosynaptic plasticity over a broad variety of time (minutes to days) and spatial scales (several micrometers). |
format | Online Article Text |
id | pubmed-4999190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-49991902016-09-12 Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression Li, Yinyun Kulvicius, Tomas Tetzlaff, Christian PLoS One Research Article The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-lasting late-phase state. The underlying processes of this synaptic consolidation are already well-known for homosynaptic plasticity, however, it is not clear whether the same processes also enable the induction and consolidation of heterosynaptic plasticity. In this study, by extending a generic calcium-based plasticity model with the processes of synaptic consolidation, we show in simulations that indeed heterosynaptic plasticity can be induced and, furthermore, consolidated by the same underlying processes as for homosynaptic plasticity. Furthermore, we show that by local diffusion processes the heterosynaptic effect can be restricted to a few synapses neighboring the homosynaptically changed ones. Taken together, this generic model reproduces many experimental results of synaptic tagging and consolidation, provides several predictions for heterosynaptic induction and consolidation, and yields insights into the complex interactions between homo- and heterosynaptic plasticity over a broad variety of time (minutes to days) and spatial scales (several micrometers). Public Library of Science 2016-08-25 /pmc/articles/PMC4999190/ /pubmed/27560350 http://dx.doi.org/10.1371/journal.pone.0161679 Text en © 2016 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Li, Yinyun Kulvicius, Tomas Tetzlaff, Christian Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression |
title | Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression |
title_full | Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression |
title_fullStr | Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression |
title_full_unstemmed | Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression |
title_short | Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression |
title_sort | induction and consolidation of calcium-based homo- and heterosynaptic potentiation and depression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999190/ https://www.ncbi.nlm.nih.gov/pubmed/27560350 http://dx.doi.org/10.1371/journal.pone.0161679 |
work_keys_str_mv | AT liyinyun inductionandconsolidationofcalciumbasedhomoandheterosynapticpotentiationanddepression AT kulviciustomas inductionandconsolidationofcalciumbasedhomoandheterosynapticpotentiationanddepression AT tetzlaffchristian inductionandconsolidationofcalciumbasedhomoandheterosynapticpotentiationanddepression |