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Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression

The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-last...

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Detalles Bibliográficos
Autores principales: Li, Yinyun, Kulvicius, Tomas, Tetzlaff, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999190/
https://www.ncbi.nlm.nih.gov/pubmed/27560350
http://dx.doi.org/10.1371/journal.pone.0161679
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author Li, Yinyun
Kulvicius, Tomas
Tetzlaff, Christian
author_facet Li, Yinyun
Kulvicius, Tomas
Tetzlaff, Christian
author_sort Li, Yinyun
collection PubMed
description The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-lasting late-phase state. The underlying processes of this synaptic consolidation are already well-known for homosynaptic plasticity, however, it is not clear whether the same processes also enable the induction and consolidation of heterosynaptic plasticity. In this study, by extending a generic calcium-based plasticity model with the processes of synaptic consolidation, we show in simulations that indeed heterosynaptic plasticity can be induced and, furthermore, consolidated by the same underlying processes as for homosynaptic plasticity. Furthermore, we show that by local diffusion processes the heterosynaptic effect can be restricted to a few synapses neighboring the homosynaptically changed ones. Taken together, this generic model reproduces many experimental results of synaptic tagging and consolidation, provides several predictions for heterosynaptic induction and consolidation, and yields insights into the complex interactions between homo- and heterosynaptic plasticity over a broad variety of time (minutes to days) and spatial scales (several micrometers).
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spelling pubmed-49991902016-09-12 Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression Li, Yinyun Kulvicius, Tomas Tetzlaff, Christian PLoS One Research Article The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-lasting late-phase state. The underlying processes of this synaptic consolidation are already well-known for homosynaptic plasticity, however, it is not clear whether the same processes also enable the induction and consolidation of heterosynaptic plasticity. In this study, by extending a generic calcium-based plasticity model with the processes of synaptic consolidation, we show in simulations that indeed heterosynaptic plasticity can be induced and, furthermore, consolidated by the same underlying processes as for homosynaptic plasticity. Furthermore, we show that by local diffusion processes the heterosynaptic effect can be restricted to a few synapses neighboring the homosynaptically changed ones. Taken together, this generic model reproduces many experimental results of synaptic tagging and consolidation, provides several predictions for heterosynaptic induction and consolidation, and yields insights into the complex interactions between homo- and heterosynaptic plasticity over a broad variety of time (minutes to days) and spatial scales (several micrometers). Public Library of Science 2016-08-25 /pmc/articles/PMC4999190/ /pubmed/27560350 http://dx.doi.org/10.1371/journal.pone.0161679 Text en © 2016 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Li, Yinyun
Kulvicius, Tomas
Tetzlaff, Christian
Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression
title Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression
title_full Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression
title_fullStr Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression
title_full_unstemmed Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression
title_short Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression
title_sort induction and consolidation of calcium-based homo- and heterosynaptic potentiation and depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999190/
https://www.ncbi.nlm.nih.gov/pubmed/27560350
http://dx.doi.org/10.1371/journal.pone.0161679
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