Cargando…

FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?

BACKGROUND: Genome-wide association studies have identified variants within the FTO (fat mass and obesity associated) locus as the strongest predictors of obesity amongst all obesity-associated gene loci. Recent evidence suggests that variants in FTO directly affect human adipocyte function through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Landgraf, Kathrin, Scholz, Markus, Kovacs, Peter, Kiess, Wieland, Körner, Antje
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999231/ https://www.ncbi.nlm.nih.gov/pubmed/27560134 http://dx.doi.org/10.1371/journal.pone.0161739

Ejemplares similares

Impact of Metabolic Regulators on the Expression of the Obesity Associated Genes FTO and NAMPT in Human Preadipocytes and Adipocytes
por: Friebe, Daniela, et al.
Publicado: (2011)

Human obesity: FTO, IRX3, or both?()
por: Cedernaes, Jonathan, et al.
Publicado: (2014)

Obesity-associated variants within FTO form long-range functional connections with IRX3
por: Smemo, Scott, et al.
Publicado: (2014)

Commentary: FTO obesity variant circuitry and adipocyte browning in humans
por: Laber, Samantha, et al.
Publicado: (2015)

Genetic association of FTO/IRX region with obesity and overweight in the Polish population
por: Sobalska-Kwapis, Marta, et al.
Publicado: (2017)

Interactions between macro-nutrients’ intake, FTO and IRX3 gene expression, and FTO genotype in obese and overweight male adolescents
por: Doaei, Saeid, et al.
Publicado: (2019)

An FTO Gene Variant Moderates the Association between Parental Restriction and Child BMI
por: Tovar, Alison, et al.
Publicado: (2016)

Changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing an intensive lifestyle intervention and the role of FTO genotype in this interaction
por: Doaei, Saeid, et al.
Publicado: (2019)

MON-092 Role of Genetic Variants of NNMT rs694539 and rs1941404, FTO rs1421085 and Irx3 rs3751723 Polymorphisms on Resting Energy Expenditure and BMI
por: Bañales Luna, Maciel, et al.
Publicado: (2019)

Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects
por: Bañales-Luna, Maciel, et al.
Publicado: (2020)

Association of serum 25-OH-vitamin D level with FTO and IRX3 genes expression in obese and overweight boys with different FTO rs9930506 genotypes
por: Gholamalizadeh, Maryam, et al.
Publicado: (2021)

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children
por: Sällman Almén, M, et al.
Publicado: (2013)

Expression of the Adipocyte Progenitor Markers MSCA1 and CD36 is Associated With Adipose Tissue Function in Children
por: Hanschkow, Martha, et al.
Publicado: (2021)

Genetic Contribution of Variants near SORT1 and APOE on LDL Cholesterol Independent of Obesity in Children
por: Breitling, Clara, et al.
Publicado: (2015)

Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children
por: da Silva, Carmela Farias, et al.
Publicado: (2013)

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents
por: Qi, Qibin, et al.
Publicado: (2015)

Effects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children
por: Windholz, Jan, et al.
Publicado: (2011)

Role of FTO in Adipocyte Development and Function: Recent Insights
por: Merkestein, Myrte, et al.
Publicado: (2015)

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals
por: Meyre, David, et al.
Publicado: (2010)

Direct Evidence of Brown Adipocytes in Different Fat Depots in Children
por: Rockstroh, Denise, et al.
Publicado: (2015)

Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children
por: Fang, Hongyun, et al.
Publicado: (2010)

FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in Singapore
por: Tan, Jonathan T., et al.
Publicado: (2008)

Association of FTO gene variants with body composition in UK twins
por: Livshits, Gregory, et al.
Publicado: (2012)

The Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro
por: Jiao, Yang, et al.
Publicado: (2016)

Case report: A novel biallelic FTO variant causing multisystem anomalies with severe epilepsy, widening the spectrum of FTO syndrome
por: Mayman, Naomi, et al.
Publicado: (2023)

Common Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females
por: Shahid, Adeela, et al.
Publicado: (2013)

Association of HTTLPR, BDNF, and FTO Genetic Variants with Completed Suicide in Slovakia
por: Bednarova, Aneta, et al.
Publicado: (2023)

FTO and PLAG1 Genes Expression and FTO Methylation Predict Changes in Circulating Levels of Adipokines and Gastrointestinal Peptides in Children
por: Czogała, Wojciech, et al.
Publicado: (2021)

The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents
por: Hallman, D. Michael, et al.
Publicado: (2011)

Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children: Results of the IDEFICS Study
por: Lauria, Fabio, et al.
Publicado: (2012)

FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis
por: Liu, Chibo, et al.
Publicado: (2013)

Eating Behaviours and Food Cravings; Influence of Age, Sex, BMI and FTO Genotype
por: Abdella, Hanan M., et al.
Publicado: (2019)

Pharmacological Inhibition of FTO
por: McMurray, Fiona, et al.
Publicado: (2015)

FTO Is a Relevant Factor for the Development of the Metabolic Syndrome in Mice
por: Ikels, Kathrin, et al.
Publicado: (2014)

The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924
por: Jacobsson, Josefin A, et al.
Publicado: (2009)

An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population
por: Klemetti, Miira, et al.
Publicado: (2011)

FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women
por: Song, Do Kyeong, et al.
Publicado: (2014)

Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease
por: Reitz, Christiane, et al.
Publicado: (2012)

Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine
por: Sabarneh, Anas, et al.
Publicado: (2018)

Effect of FTO rs9939609 variant on insulin resistance in obese female adolescents
por: Iskandar, Kristy, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ledsmjdh11sufee0qeap056arc