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Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome
The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain–Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999274/ https://www.ncbi.nlm.nih.gov/pubmed/27560129 http://dx.doi.org/10.1371/journal.pntd.0004877 |
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author | Klase, Zachary A. Khakhina, Svetlana Schneider, Adriano De Bernardi Callahan, Michael V. Glasspool-Malone, Jill Malone, Robert |
author_facet | Klase, Zachary A. Khakhina, Svetlana Schneider, Adriano De Bernardi Callahan, Michael V. Glasspool-Malone, Jill Malone, Robert |
author_sort | Klase, Zachary A. |
collection | PubMed |
description | The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain–Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in the Zika virus outbreak, larger prospective epidemiology and basic virology studies examining the mechanisms of Zika viral infection and associated pathophysiology are only now starting to be published. In this review, we analyze Zika fetal neuropathogenesis from a comparative pathology perspective, using the historic metaphor of “TORCH” viral pathogenesis to provide context. By drawing parallels to other viral infections of the fetus, we identify common themes and mechanisms that may illuminate the observed pathology. The existing data on the susceptibility of various cells to both Zika and other flavivirus infections are summarized. Finally, we highlight relevant aspects of the known molecular mechanisms of flavivirus replication. |
format | Online Article Text |
id | pubmed-4999274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-49992742016-09-12 Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome Klase, Zachary A. Khakhina, Svetlana Schneider, Adriano De Bernardi Callahan, Michael V. Glasspool-Malone, Jill Malone, Robert PLoS Negl Trop Dis Review The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain–Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in the Zika virus outbreak, larger prospective epidemiology and basic virology studies examining the mechanisms of Zika viral infection and associated pathophysiology are only now starting to be published. In this review, we analyze Zika fetal neuropathogenesis from a comparative pathology perspective, using the historic metaphor of “TORCH” viral pathogenesis to provide context. By drawing parallels to other viral infections of the fetus, we identify common themes and mechanisms that may illuminate the observed pathology. The existing data on the susceptibility of various cells to both Zika and other flavivirus infections are summarized. Finally, we highlight relevant aspects of the known molecular mechanisms of flavivirus replication. Public Library of Science 2016-08-25 /pmc/articles/PMC4999274/ /pubmed/27560129 http://dx.doi.org/10.1371/journal.pntd.0004877 Text en © 2016 Klase et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Klase, Zachary A. Khakhina, Svetlana Schneider, Adriano De Bernardi Callahan, Michael V. Glasspool-Malone, Jill Malone, Robert Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome |
title | Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome |
title_full | Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome |
title_fullStr | Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome |
title_full_unstemmed | Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome |
title_short | Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome |
title_sort | zika fetal neuropathogenesis: etiology of a viral syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999274/ https://www.ncbi.nlm.nih.gov/pubmed/27560129 http://dx.doi.org/10.1371/journal.pntd.0004877 |
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