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PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

Invasive lobular carcinoma (ILC) is an aggressive breast cancer subtype with poor response to chemotherapy. Besides loss of E-cadherin, a hallmark of ILC, genetic inactivation of PTEN is frequently observed in patients. Through concomitant Cre-mediated inactivation of E-cadherin and PTEN in mammary...

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Detalles Bibliográficos
Autores principales:	Boelens, Mirjam C., Nethe, Micha, Klarenbeek, Sjoerd, de Ruiter, Julian R., Schut, Eva, Bonzanni, Nicola, Zeeman, Amber L., Wientjens, Ellen, van der Burg, Eline, Wessels, Lodewyk, van Amerongen, Renée, Jonkers, Jos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999419/ https://www.ncbi.nlm.nih.gov/pubmed/27524621 http://dx.doi.org/10.1016/j.celrep.2016.07.059

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