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Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy

The log odds of positive lymph nodes (LODDS) was defined as the log of the ratio between the number of positive lymph nodes and the number of negative lymph nodes, which is a novel and promising nodal staging system for gastric cancer. Here, we aimed to compare the prognostic effect of pN, lymph nod...

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Autores principales: Jian-hui, Chen, Shi-rong, Cai, Hui, Wu, Si-le, Chen, Jian-bo, Xu, Er-tao, Zhai, Chuang-qi, Chen, Yu-long, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999458/
https://www.ncbi.nlm.nih.gov/pubmed/26912060
http://dx.doi.org/10.1007/s13277-015-4191-7
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author Jian-hui, Chen
Shi-rong, Cai
Hui, Wu
Si-le, Chen
Jian-bo, Xu
Er-tao, Zhai
Chuang-qi, Chen
Yu-long, He
author_facet Jian-hui, Chen
Shi-rong, Cai
Hui, Wu
Si-le, Chen
Jian-bo, Xu
Er-tao, Zhai
Chuang-qi, Chen
Yu-long, He
author_sort Jian-hui, Chen
collection PubMed
description The log odds of positive lymph nodes (LODDS) was defined as the log of the ratio between the number of positive lymph nodes and the number of negative lymph nodes, which is a novel and promising nodal staging system for gastric cancer. Here, we aimed to compare the prognostic effect of pN, lymph node ratio (LNR) and LODDS. The association between overall survival and pN, LNR and LODDS was retrospectively analysed. The discriminatory ability and monotonicity of gradients (linear trend χ (2) score), homogeneity ability (likelihood ratio test) and prognostic stratification ability (Akaike information criterion [AIC] and receiver operating characteristic [ROC] curve) were compared among three lymph node staging systems. The pN, LNR and LODDS were all identified as independent prognostic factors for gastric cancer patients in the multivariate analysis. LODDS showed the best prognostic performance (linear trend χ (2) score 266.743, likelihood ratio χ (2) test score 427.771, AIC value 5670.226, area under the curve (AUC) 0.793), followed by LNR and pN. In patients with different levels of retrieved lymph nodes (≤10, 11–14, 15–25 and >25), LODDS was the most powerful for prognostic prediction and discrimination of the heterogeneity among the subgroups. Significant differences in survival were observed among patients in different LODDS subgroups after being classified according to the pN and LNR classifications. LODDS appears to be a more powerful system for predicting the overall survival of gastric cancer patients, as compared to LNR and pN, and may serve as an alternative nodal staging system for gastric cancer.
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spelling pubmed-49994582016-09-12 Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy Jian-hui, Chen Shi-rong, Cai Hui, Wu Si-le, Chen Jian-bo, Xu Er-tao, Zhai Chuang-qi, Chen Yu-long, He Tumour Biol Original Article The log odds of positive lymph nodes (LODDS) was defined as the log of the ratio between the number of positive lymph nodes and the number of negative lymph nodes, which is a novel and promising nodal staging system for gastric cancer. Here, we aimed to compare the prognostic effect of pN, lymph node ratio (LNR) and LODDS. The association between overall survival and pN, LNR and LODDS was retrospectively analysed. The discriminatory ability and monotonicity of gradients (linear trend χ (2) score), homogeneity ability (likelihood ratio test) and prognostic stratification ability (Akaike information criterion [AIC] and receiver operating characteristic [ROC] curve) were compared among three lymph node staging systems. The pN, LNR and LODDS were all identified as independent prognostic factors for gastric cancer patients in the multivariate analysis. LODDS showed the best prognostic performance (linear trend χ (2) score 266.743, likelihood ratio χ (2) test score 427.771, AIC value 5670.226, area under the curve (AUC) 0.793), followed by LNR and pN. In patients with different levels of retrieved lymph nodes (≤10, 11–14, 15–25 and >25), LODDS was the most powerful for prognostic prediction and discrimination of the heterogeneity among the subgroups. Significant differences in survival were observed among patients in different LODDS subgroups after being classified according to the pN and LNR classifications. LODDS appears to be a more powerful system for predicting the overall survival of gastric cancer patients, as compared to LNR and pN, and may serve as an alternative nodal staging system for gastric cancer. Springer Netherlands 2016-02-24 /pmc/articles/PMC4999458/ /pubmed/26912060 http://dx.doi.org/10.1007/s13277-015-4191-7 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Jian-hui, Chen
Shi-rong, Cai
Hui, Wu
Si-le, Chen
Jian-bo, Xu
Er-tao, Zhai
Chuang-qi, Chen
Yu-long, He
Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy
title Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy
title_full Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy
title_fullStr Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy
title_full_unstemmed Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy
title_short Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy
title_sort prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following d2 lymphadenectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999458/
https://www.ncbi.nlm.nih.gov/pubmed/26912060
http://dx.doi.org/10.1007/s13277-015-4191-7
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