Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells

Crosslinking of B-cell receptor (BCR) sets off an apoptosis programme, but the underlying pathways remain obscure. Here we decipher the molecular mechanisms bridging B-cell activation and apoptosis mediated by post-translational modification (PTM). We find that O-GlcNAcase inhibition enhances B-cell...

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Detalles Bibliográficos
Autores principales: Wu, Jung-Lin, Wu, Hsin-Yi, Tsai, Dong-Yan, Chiang, Ming-Feng, Chen, Yi-Ju, Gao, Shijay, Lin, Chun-Cheng, Lin, Chun-Hung, Khoo, Kay-Hooi, Chen, Yu-Ju, Lin, Kuo-I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999498/
https://www.ncbi.nlm.nih.gov/pubmed/27555448
http://dx.doi.org/10.1038/ncomms12526

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