Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis

Optineurin (OPTN) mutations cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and glaucoma. Although the ALS-associated E478G mutation in the UBAN domain of OPTN reportedly abolishes its NF-κB suppressive activity, the precise molecular basis in ALS pathogenesis still r...

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Detalles Bibliográficos
Autores principales: Nakazawa, Seshiru, Oikawa, Daisuke, Ishii, Ryohei, Ayaki, Takashi, Takahashi, Hirotaka, Takeda, Hiroyuki, Ishitani, Ryuichiro, Kamei, Kiyoko, Takeyoshi, Izumi, Kawakami, Hideshi, Iwai, Kazuhiro, Hatada, Izuho, Sawasaki, Tatsuya, Ito, Hidefumi, Nureki, Osamu, Tokunaga, Fuminori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999505/
https://www.ncbi.nlm.nih.gov/pubmed/27552911
http://dx.doi.org/10.1038/ncomms12547

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