Developmental Drift and the Role of Wnt Signaling in Aging

Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift the...

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Detalles Bibliográficos
Autores principales: Gruber, Jan, Yee, Zhuangli, Tolwinski, Nicholas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999782/
https://www.ncbi.nlm.nih.gov/pubmed/27490570
http://dx.doi.org/10.3390/cancers8080073
Descripción
Sumario:Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift theory of aging, and the links that have been established between aging and the Wnt signaling pathways. We focus on insights derived from model organisms connecting the evolutionary basis of aging and the link to developmental programming.

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