Developmental Drift and the Role of Wnt Signaling in Aging

Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift the...

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Detalles Bibliográficos
Autores principales: Gruber, Jan, Yee, Zhuangli, Tolwinski, Nicholas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999782/
https://www.ncbi.nlm.nih.gov/pubmed/27490570
http://dx.doi.org/10.3390/cancers8080073
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author Gruber, Jan
Yee, Zhuangli
Tolwinski, Nicholas S.
author_facet Gruber, Jan
Yee, Zhuangli
Tolwinski, Nicholas S.
author_sort Gruber, Jan
collection PubMed
description Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift theory of aging, and the links that have been established between aging and the Wnt signaling pathways. We focus on insights derived from model organisms connecting the evolutionary basis of aging and the link to developmental programming.
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spelling pubmed-49997822016-09-01 Developmental Drift and the Role of Wnt Signaling in Aging Gruber, Jan Yee, Zhuangli Tolwinski, Nicholas S. Cancers (Basel) Review Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift theory of aging, and the links that have been established between aging and the Wnt signaling pathways. We focus on insights derived from model organisms connecting the evolutionary basis of aging and the link to developmental programming. MDPI 2016-08-02 /pmc/articles/PMC4999782/ /pubmed/27490570 http://dx.doi.org/10.3390/cancers8080073 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gruber, Jan
Yee, Zhuangli
Tolwinski, Nicholas S.
Developmental Drift and the Role of Wnt Signaling in Aging
title Developmental Drift and the Role of Wnt Signaling in Aging
title_full Developmental Drift and the Role of Wnt Signaling in Aging
title_fullStr Developmental Drift and the Role of Wnt Signaling in Aging
title_full_unstemmed Developmental Drift and the Role of Wnt Signaling in Aging
title_short Developmental Drift and the Role of Wnt Signaling in Aging
title_sort developmental drift and the role of wnt signaling in aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999782/
https://www.ncbi.nlm.nih.gov/pubmed/27490570
http://dx.doi.org/10.3390/cancers8080073
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