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The Role of the C-Clamp in Wnt-Related Colorectal Cancers

T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their...

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Autores principales: Ravindranath, Aditi J., Cadigan, Ken M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999783/
https://www.ncbi.nlm.nih.gov/pubmed/27527215
http://dx.doi.org/10.3390/cancers8080074
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author Ravindranath, Aditi J.
Cadigan, Ken M.
author_facet Ravindranath, Aditi J.
Cadigan, Ken M.
author_sort Ravindranath, Aditi J.
collection PubMed
description T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their high mobility group (HMG) domains, but invertebrate TCFs and some isoforms of vertebrate TCF7 and TCF7L2 contain a second DNA binding domain known as the C-clamp. This review will cover the basic properties of C-clamps and their importance in Wnt signaling, using data from Drosophila, C. elegans, and mammalian cell culture. The connection between C-clamp containing TCFs and colorectal cancer will also be discussed.
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spelling pubmed-49997832016-09-01 The Role of the C-Clamp in Wnt-Related Colorectal Cancers Ravindranath, Aditi J. Cadigan, Ken M. Cancers (Basel) Review T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their high mobility group (HMG) domains, but invertebrate TCFs and some isoforms of vertebrate TCF7 and TCF7L2 contain a second DNA binding domain known as the C-clamp. This review will cover the basic properties of C-clamps and their importance in Wnt signaling, using data from Drosophila, C. elegans, and mammalian cell culture. The connection between C-clamp containing TCFs and colorectal cancer will also be discussed. MDPI 2016-08-03 /pmc/articles/PMC4999783/ /pubmed/27527215 http://dx.doi.org/10.3390/cancers8080074 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ravindranath, Aditi J.
Cadigan, Ken M.
The Role of the C-Clamp in Wnt-Related Colorectal Cancers
title The Role of the C-Clamp in Wnt-Related Colorectal Cancers
title_full The Role of the C-Clamp in Wnt-Related Colorectal Cancers
title_fullStr The Role of the C-Clamp in Wnt-Related Colorectal Cancers
title_full_unstemmed The Role of the C-Clamp in Wnt-Related Colorectal Cancers
title_short The Role of the C-Clamp in Wnt-Related Colorectal Cancers
title_sort role of the c-clamp in wnt-related colorectal cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999783/
https://www.ncbi.nlm.nih.gov/pubmed/27527215
http://dx.doi.org/10.3390/cancers8080074
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