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Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC

Folate deficiency in fetal life is strongly associated with structural malformations and linked to intrauterine growth restriction. In addition, limited availability of methyl donors, such as folate, during pregnancy may result in abnormal gene methylation patterns and contribute to developmental pr...

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Detalles Bibliográficos
Autores principales:	Rosario, Fredrick J., Powell, Theresa L., Jansson, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999868/ https://www.ncbi.nlm.nih.gov/pubmed/27562465 http://dx.doi.org/10.1038/srep31705

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