A virus-like particle-based connective tissue growth factor vaccine suppresses carbon tetrachloride-induced hepatic fibrosis in mice

Connective tissue growth factor (CTGF) has been recognized as a central mediator and promising therapeutic target in hepatic fibrosis. In this study, we generated a novel virus-like particle (VLP) CTGF vaccine by inserting the 138–159 amino acid (aa) fragment of CTGF into the central c/e1 epitope of...

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Detalles Bibliográficos
Autores principales: Li, Shuang, Lv, Yi-Fei, Su, Hou-Qiang, Zhang, Qian-Nan, Wang, Li-Rong, Hao, Zhi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999884/
https://www.ncbi.nlm.nih.gov/pubmed/27562139
http://dx.doi.org/10.1038/srep32155

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