Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.

Three new polyhydroxylated sterol derivatives topsensterols A–C (1–3) have been isolated from a marine sponge Topsentia sp. collected from the South China Sea. Their structures were elucidated by detailed analysis of the spectroscopic data, especially the NOESY spectra. Topsensterols A–C (l–3) posse...

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Detalles Bibliográficos
Autores principales: Chen, Min, Wu, Xu-Dong, Zhao, Qing, Wang, Chang-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999907/
https://www.ncbi.nlm.nih.gov/pubmed/27490555
http://dx.doi.org/10.3390/md14080146
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author Chen, Min
Wu, Xu-Dong
Zhao, Qing
Wang, Chang-Yun
author_facet Chen, Min
Wu, Xu-Dong
Zhao, Qing
Wang, Chang-Yun
author_sort Chen, Min
collection PubMed
description Three new polyhydroxylated sterol derivatives topsensterols A–C (1–3) have been isolated from a marine sponge Topsentia sp. collected from the South China Sea. Their structures were elucidated by detailed analysis of the spectroscopic data, especially the NOESY spectra. Topsensterols A–C (l–3) possess novel 2β,3α,4β,6α-tetrahydroxy-14α-methyl Δ(9(11)) steroidal nuclei with unusual side chains. Compound 2 exhibited cytotoxicity against human gastric carcinoma cell line SGC-7901 with an IC(50) value of 8.0 μM. Compound 3 displayed cytotoxicity against human erythroleukemia cell line K562 with an IC(50) value of 6.0 μM.
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spelling pubmed-49999072016-09-01 Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp. Chen, Min Wu, Xu-Dong Zhao, Qing Wang, Chang-Yun Mar Drugs Article Three new polyhydroxylated sterol derivatives topsensterols A–C (1–3) have been isolated from a marine sponge Topsentia sp. collected from the South China Sea. Their structures were elucidated by detailed analysis of the spectroscopic data, especially the NOESY spectra. Topsensterols A–C (l–3) possess novel 2β,3α,4β,6α-tetrahydroxy-14α-methyl Δ(9(11)) steroidal nuclei with unusual side chains. Compound 2 exhibited cytotoxicity against human gastric carcinoma cell line SGC-7901 with an IC(50) value of 8.0 μM. Compound 3 displayed cytotoxicity against human erythroleukemia cell line K562 with an IC(50) value of 6.0 μM. MDPI 2016-08-01 /pmc/articles/PMC4999907/ /pubmed/27490555 http://dx.doi.org/10.3390/md14080146 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Min
Wu, Xu-Dong
Zhao, Qing
Wang, Chang-Yun
Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
title Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
title_full Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
title_fullStr Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
title_full_unstemmed Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
title_short Topsensterols A–C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.
title_sort topsensterols a–c, cytotoxic polyhydroxylated sterol derivatives from a marine sponge topsentia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999907/
https://www.ncbi.nlm.nih.gov/pubmed/27490555
http://dx.doi.org/10.3390/md14080146
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