Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2)

Individuals with poor postnatal growth are at risk for cardiovascular and metabolic problems as adults. Here we show that disruption of the molecular scaffold Kinase Suppressor of Ras 2 (KSR2) causes selective inhibition of hepatic GH signaling in neonatal mice with impaired expression of IGF-1 and...

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Detalles Bibliográficos
Autores principales: Guo, Lili, Costanzo-Garvey, Diane L., Smith, Deandra R., Zavorka, Megan E., Venable-Kang, Megan, MacDonald, Richard G., Lewis, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999994/
https://www.ncbi.nlm.nih.gov/pubmed/27561547
http://dx.doi.org/10.1038/srep32093

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