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Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000668/ https://www.ncbi.nlm.nih.gov/pubmed/27548150 http://dx.doi.org/10.3390/ijms17081270 |
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author | Veras, Patrícia Sampaio Tavares Bezerra de Menezes, Juliana Perrone |
author_facet | Veras, Patrícia Sampaio Tavares Bezerra de Menezes, Juliana Perrone |
author_sort | Veras, Patrícia Sampaio Tavares |
collection | PubMed |
description | Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania, as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival. |
format | Online Article Text |
id | pubmed-5000668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50006682016-09-01 Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection Veras, Patrícia Sampaio Tavares Bezerra de Menezes, Juliana Perrone Int J Mol Sci Review Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania, as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival. MDPI 2016-08-19 /pmc/articles/PMC5000668/ /pubmed/27548150 http://dx.doi.org/10.3390/ijms17081270 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Veras, Patrícia Sampaio Tavares Bezerra de Menezes, Juliana Perrone Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title | Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_full | Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_fullStr | Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_full_unstemmed | Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_short | Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection |
title_sort | using proteomics to understand how leishmania parasites survive inside the host and establish infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000668/ https://www.ncbi.nlm.nih.gov/pubmed/27548150 http://dx.doi.org/10.3390/ijms17081270 |
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