The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity

In humans, the ribonuclease A (RNase A) superfamily contains eight different members that have RNase activities, and all of these members are encoded on chromosome 14. The proteins are secreted by a large variety of different tissues and cells; however, a comprehensive understanding of these protein...

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Autores principales: Koczera, Patrick, Martin, Lukas, Marx, Gernot, Schuerholz, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000675/
https://www.ncbi.nlm.nih.gov/pubmed/27527162
http://dx.doi.org/10.3390/ijms17081278
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author Koczera, Patrick
Martin, Lukas
Marx, Gernot
Schuerholz, Tobias
author_facet Koczera, Patrick
Martin, Lukas
Marx, Gernot
Schuerholz, Tobias
author_sort Koczera, Patrick
collection PubMed
description In humans, the ribonuclease A (RNase A) superfamily contains eight different members that have RNase activities, and all of these members are encoded on chromosome 14. The proteins are secreted by a large variety of different tissues and cells; however, a comprehensive understanding of these proteins’ physiological roles is lacking. Different biological effects can be attributed to each protein, including antiviral, antibacterial and antifungal activities as well as cytotoxic effects against host cells and parasites. Different immunomodulatory effects have also been demonstrated. This review summarizes the available data on the human RNase A superfamily and illustrates the significant role of the eight canonical RNases in inflammation and the host defence system against infections.
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spelling pubmed-50006752016-09-01 The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity Koczera, Patrick Martin, Lukas Marx, Gernot Schuerholz, Tobias Int J Mol Sci Review In humans, the ribonuclease A (RNase A) superfamily contains eight different members that have RNase activities, and all of these members are encoded on chromosome 14. The proteins are secreted by a large variety of different tissues and cells; however, a comprehensive understanding of these proteins’ physiological roles is lacking. Different biological effects can be attributed to each protein, including antiviral, antibacterial and antifungal activities as well as cytotoxic effects against host cells and parasites. Different immunomodulatory effects have also been demonstrated. This review summarizes the available data on the human RNase A superfamily and illustrates the significant role of the eight canonical RNases in inflammation and the host defence system against infections. MDPI 2016-08-05 /pmc/articles/PMC5000675/ /pubmed/27527162 http://dx.doi.org/10.3390/ijms17081278 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koczera, Patrick
Martin, Lukas
Marx, Gernot
Schuerholz, Tobias
The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity
title The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity
title_full The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity
title_fullStr The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity
title_full_unstemmed The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity
title_short The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity
title_sort ribonuclease a superfamily in humans: canonical rnases as the buttress of innate immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000675/
https://www.ncbi.nlm.nih.gov/pubmed/27527162
http://dx.doi.org/10.3390/ijms17081278
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