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Epigenetic Modifications of Major Depressive Disorder
Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evid...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000676/ https://www.ncbi.nlm.nih.gov/pubmed/27527165 http://dx.doi.org/10.3390/ijms17081279 |
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author | Saavedra, Kathleen Molina-Márquez, Ana María Saavedra, Nicolás Zambrano, Tomás Salazar, Luis A. |
author_facet | Saavedra, Kathleen Molina-Márquez, Ana María Saavedra, Nicolás Zambrano, Tomás Salazar, Luis A. |
author_sort | Saavedra, Kathleen |
collection | PubMed |
description | Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression could favor MDD advance in response to stressful experiences and environmental factors. The aim of this review is to describe genetic alterations, and particularly altered epigenetic mechanisms, that could be determinants for MDD progress, and how these alterations may arise as useful screening, diagnosis and treatment monitoring biomarkers of depressive disorders. |
format | Online Article Text |
id | pubmed-5000676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50006762016-09-01 Epigenetic Modifications of Major Depressive Disorder Saavedra, Kathleen Molina-Márquez, Ana María Saavedra, Nicolás Zambrano, Tomás Salazar, Luis A. Int J Mol Sci Review Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression could favor MDD advance in response to stressful experiences and environmental factors. The aim of this review is to describe genetic alterations, and particularly altered epigenetic mechanisms, that could be determinants for MDD progress, and how these alterations may arise as useful screening, diagnosis and treatment monitoring biomarkers of depressive disorders. MDPI 2016-08-05 /pmc/articles/PMC5000676/ /pubmed/27527165 http://dx.doi.org/10.3390/ijms17081279 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Saavedra, Kathleen Molina-Márquez, Ana María Saavedra, Nicolás Zambrano, Tomás Salazar, Luis A. Epigenetic Modifications of Major Depressive Disorder |
title | Epigenetic Modifications of Major Depressive Disorder |
title_full | Epigenetic Modifications of Major Depressive Disorder |
title_fullStr | Epigenetic Modifications of Major Depressive Disorder |
title_full_unstemmed | Epigenetic Modifications of Major Depressive Disorder |
title_short | Epigenetic Modifications of Major Depressive Disorder |
title_sort | epigenetic modifications of major depressive disorder |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000676/ https://www.ncbi.nlm.nih.gov/pubmed/27527165 http://dx.doi.org/10.3390/ijms17081279 |
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