ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier

The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells result...

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Detalles Bibliográficos
Autores principales: Drolez, Aurore, Vandenhaute, Elodie, Delannoy, Clément Philippe, Dewald, Justine Hélène, Gosselet, Fabien, Cecchelli, Romeo, Julien, Sylvain, Dehouck, Marie-Pierre, Delannoy, Philippe, Mysiorek, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000706/
https://www.ncbi.nlm.nih.gov/pubmed/27529215
http://dx.doi.org/10.3390/ijms17081309
Descripción
Sumario:The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of G(D1α) ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34(+) derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier.

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