ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier

The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells result...

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Autores principales: Drolez, Aurore, Vandenhaute, Elodie, Delannoy, Clément Philippe, Dewald, Justine Hélène, Gosselet, Fabien, Cecchelli, Romeo, Julien, Sylvain, Dehouck, Marie-Pierre, Delannoy, Philippe, Mysiorek, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000706/
https://www.ncbi.nlm.nih.gov/pubmed/27529215
http://dx.doi.org/10.3390/ijms17081309
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author Drolez, Aurore
Vandenhaute, Elodie
Delannoy, Clément Philippe
Dewald, Justine Hélène
Gosselet, Fabien
Cecchelli, Romeo
Julien, Sylvain
Dehouck, Marie-Pierre
Delannoy, Philippe
Mysiorek, Caroline
author_facet Drolez, Aurore
Vandenhaute, Elodie
Delannoy, Clément Philippe
Dewald, Justine Hélène
Gosselet, Fabien
Cecchelli, Romeo
Julien, Sylvain
Dehouck, Marie-Pierre
Delannoy, Philippe
Mysiorek, Caroline
author_sort Drolez, Aurore
collection PubMed
description The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of G(D1α) ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34(+) derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier.
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spelling pubmed-50007062016-09-01 ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier Drolez, Aurore Vandenhaute, Elodie Delannoy, Clément Philippe Dewald, Justine Hélène Gosselet, Fabien Cecchelli, Romeo Julien, Sylvain Dehouck, Marie-Pierre Delannoy, Philippe Mysiorek, Caroline Int J Mol Sci Article The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of G(D1α) ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34(+) derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier. MDPI 2016-08-11 /pmc/articles/PMC5000706/ /pubmed/27529215 http://dx.doi.org/10.3390/ijms17081309 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Drolez, Aurore
Vandenhaute, Elodie
Delannoy, Clément Philippe
Dewald, Justine Hélène
Gosselet, Fabien
Cecchelli, Romeo
Julien, Sylvain
Dehouck, Marie-Pierre
Delannoy, Philippe
Mysiorek, Caroline
ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
title ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
title_full ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
title_fullStr ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
title_full_unstemmed ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
title_short ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier
title_sort st6galnac5 expression decreases the interactions between breast cancer cells and the human blood-brain barrier
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000706/
https://www.ncbi.nlm.nih.gov/pubmed/27529215
http://dx.doi.org/10.3390/ijms17081309
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