Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Pancreatic islet β-cells are particularly susceptible to endoplasmic reticulum (ER) stress, which is implicated in β-cell dysfunction and loss during the pathogenesis of type 1 diabetes (T1D). The peripheral membrane protein GAD65 is an autoantigen in human T1D. GAD65 synthesizes γ-aminobutyric acid...

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Detalles Bibliográficos
Autores principales: Phelps, Edward A., Cianciaruso, Chiara, Michael, Iacovos P., Pasquier, Miriella, Kanaani, Jamil, Nano, Rita, Lavallard, Vanessa, Billestrup, Nils, Hubbell, Jeffrey A., Baekkeskov, Steinunn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001175/
https://www.ncbi.nlm.nih.gov/pubmed/27284108
http://dx.doi.org/10.2337/db16-0180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001175/
https://www.ncbi.nlm.nih.gov/pubmed/27284108
http://dx.doi.org/10.2337/db16-0180

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