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Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity

Alterations in dopaminergic circuitry play a critical role in food reward and may contribute to susceptibility to obesity. Ingestion of sweets releases dopamine in striatum, and both sweet preferences and striatal D(2) receptors (D2R) decline with age and may be altered in obesity. Understanding the...

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Autores principales: Pepino, Marta Y., Eisenstein, Sarah A., Bischoff, Allison N., Klein, Samuel, Moerlein, Stephen M., Perlmutter, Joel S., Black, Kevin J., Hershey, Tamara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001180/
https://www.ncbi.nlm.nih.gov/pubmed/27307220
http://dx.doi.org/10.2337/db16-0407
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author Pepino, Marta Y.
Eisenstein, Sarah A.
Bischoff, Allison N.
Klein, Samuel
Moerlein, Stephen M.
Perlmutter, Joel S.
Black, Kevin J.
Hershey, Tamara
author_facet Pepino, Marta Y.
Eisenstein, Sarah A.
Bischoff, Allison N.
Klein, Samuel
Moerlein, Stephen M.
Perlmutter, Joel S.
Black, Kevin J.
Hershey, Tamara
author_sort Pepino, Marta Y.
collection PubMed
description Alterations in dopaminergic circuitry play a critical role in food reward and may contribute to susceptibility to obesity. Ingestion of sweets releases dopamine in striatum, and both sweet preferences and striatal D(2) receptors (D2R) decline with age and may be altered in obesity. Understanding the relationships between these variables and the impact of obesity on these relationships may reveal insight into the neurobiological basis of sweet preferences. We evaluated sucrose preferences, perception of sweetness intensity, and striatal D2R binding potential (D2R BP(ND)) using positron emission tomography with a D2R-selective radioligand insensitive to endogenous dopamine, (N-[(11)C] methyl)benperidol, in 20 subjects without obesity (BMI 22.5 ± 2.4 kg/m(2); age 28.3 ± 5.4 years) and 24 subjects with obesity (BMI 40.3 ± 5.0 kg/m(2); age 31.2 ± 6.3 years). The groups had similar sucrose preferences, sweetness intensity perception, striatal D2R BP(ND), and age-related D2R BP(ND) declines. However, both striatal D2R BP(ND) and age correlated with sucrose preferences in subjects without obesity, explaining 52% of their variance in sucrose preference. In contrast, these associations were absent in the obese group. In conclusion, the age-related decline in D2R was not linked to the age-related decline in sweetness preferences, suggesting that other, as-yet-unknown mechanisms play a role and that these mechanisms are disrupted in obesity.
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spelling pubmed-50011802017-09-01 Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity Pepino, Marta Y. Eisenstein, Sarah A. Bischoff, Allison N. Klein, Samuel Moerlein, Stephen M. Perlmutter, Joel S. Black, Kevin J. Hershey, Tamara Diabetes Obesity Studies Alterations in dopaminergic circuitry play a critical role in food reward and may contribute to susceptibility to obesity. Ingestion of sweets releases dopamine in striatum, and both sweet preferences and striatal D(2) receptors (D2R) decline with age and may be altered in obesity. Understanding the relationships between these variables and the impact of obesity on these relationships may reveal insight into the neurobiological basis of sweet preferences. We evaluated sucrose preferences, perception of sweetness intensity, and striatal D2R binding potential (D2R BP(ND)) using positron emission tomography with a D2R-selective radioligand insensitive to endogenous dopamine, (N-[(11)C] methyl)benperidol, in 20 subjects without obesity (BMI 22.5 ± 2.4 kg/m(2); age 28.3 ± 5.4 years) and 24 subjects with obesity (BMI 40.3 ± 5.0 kg/m(2); age 31.2 ± 6.3 years). The groups had similar sucrose preferences, sweetness intensity perception, striatal D2R BP(ND), and age-related D2R BP(ND) declines. However, both striatal D2R BP(ND) and age correlated with sucrose preferences in subjects without obesity, explaining 52% of their variance in sucrose preference. In contrast, these associations were absent in the obese group. In conclusion, the age-related decline in D2R was not linked to the age-related decline in sweetness preferences, suggesting that other, as-yet-unknown mechanisms play a role and that these mechanisms are disrupted in obesity. American Diabetes Association 2016-09 2016-06-15 /pmc/articles/PMC5001180/ /pubmed/27307220 http://dx.doi.org/10.2337/db16-0407 Text en © 2016 by the American Diabetes Association. http://diabetesjournals.org/site/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://diabetesjournals.org/site/license.
spellingShingle Obesity Studies
Pepino, Marta Y.
Eisenstein, Sarah A.
Bischoff, Allison N.
Klein, Samuel
Moerlein, Stephen M.
Perlmutter, Joel S.
Black, Kevin J.
Hershey, Tamara
Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity
title Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity
title_full Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity
title_fullStr Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity
title_full_unstemmed Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity
title_short Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D(2) Receptor Binding and Age in Obesity
title_sort sweet dopamine: sucrose preferences relate differentially to striatal d(2) receptor binding and age in obesity
topic Obesity Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001180/
https://www.ncbi.nlm.nih.gov/pubmed/27307220
http://dx.doi.org/10.2337/db16-0407
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