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Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury
Hypersecretion of amylin is common in individuals with prediabetes, causes amylin deposition and proteotoxicity in pancreatic islets, and contributes to the development of type 2 diabetes. Recent studies also identified amylin deposits in failing hearts from patients with obesity or type 2 diabetes...
Autores principales: | Liu, Miao, Verma, Nirmal, Peng, Xiaoli, Srodulski, Sarah, Morris, Andrew, Chow, Martin, Hersh, Louis B., Chen, Jing, Zhu, Haining, Netea, Mihai G., Margulies, Kenneth B., Despa, Sanda, Despa, Florin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001184/ https://www.ncbi.nlm.nih.gov/pubmed/27335231 http://dx.doi.org/10.2337/db16-0044 |
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