Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance

The effect of enhancing insulin’s actions in endothelial cells (ECs) to improve angiogenesis and wound healing was studied in obesity and diabetes. Insulin receptor substrate 1 (IRS1) was overexpressed in ECs using the VE-cadherin promoter to create ECIRS1 TG mice, which elevated pAkt activation and...

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Detalles Bibliográficos
Autores principales: Katagiri, Sayaka, Park, Kyoungmin, Maeda, Yasutaka, Rao, Tata Nageswara, Khamaisi, Mogher, Li, Qian, Yokomizo, Hisashi, Mima, Akira, Lancerotto, Luca, Wagers, Amy, Orgill, Dennis P., King, George L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001189/
https://www.ncbi.nlm.nih.gov/pubmed/27217486
http://dx.doi.org/10.2337/db15-1721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001189/
https://www.ncbi.nlm.nih.gov/pubmed/27217486
http://dx.doi.org/10.2337/db15-1721

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