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Structure-guided selection of specificity determining positions in the human Kinome
BACKGROUND: The human kinome contains many important drug targets. It is well-known that inhibitors of protein kinases bind with very different selectivity profiles. This is also the case for inhibitors of many other protein families. The increased availability of protein 3D structures has provided...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001202/ https://www.ncbi.nlm.nih.gov/pubmed/27556159 http://dx.doi.org/10.1186/s12864-016-2790-3 |