An integrative genomics approach for identifying novel functional consequences of PBRM1 truncated mutations in clear cell renal cell carcinoma (ccRCC)

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Recent large-scale next-generation sequencing analyses reveal that PBRM1 is the second most frequently mutated gene harboring many truncated mutations and has a suspected tumor suppressor role in ccRCC. How...

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Detalles Bibliográficos
Autores principales: Wang, Yuanyuan, Guo, Xingyi, Bray, Michael J., Ding, Zhiyong, Zhao, Zhongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001239/
https://www.ncbi.nlm.nih.gov/pubmed/27556922
http://dx.doi.org/10.1186/s12864-016-2906-9

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