Cargando…

Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells

Diabetes mellitus is a complex and heterogeneous disease, which has β-cell dysfunction at its core. Glucotoxicity affects pancreatic islets, causing β-cell apoptosis. However, the role of JNK/β-catenin signaling in glucotoxic β-cell apoptosis is not well understood. Recently, we identified tetraspan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hwang, In-Hu, Park, Junsoo, Kim, Jung Min, Kim, Seung Il, Choi, Jong-Soon, Lee, Kyung-Bok, Yun, Sung Ho, Lee, Min-Goo, Park, Soo Jung, Jang, Ik-Soon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001516/ https://www.ncbi.nlm.nih.gov/pubmed/27247127 http://dx.doi.org/10.1096/fj.201600240RR

Ejemplares similares

Lin28a ameliorates glucotoxicity-induced β-cell dysfunction and apoptosis
por: Hwang, Yeo Jin, et al.
Publicado: (2021)

Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma
por: Joo, Jong Cheon, et al.
Publicado: (2017)

Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIP(L) expression
por: Hwang, In-Hu, et al.
Publicado: (2017)

Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer
por: Kang, Hyeon Woong, et al.
Publicado: (2023)

The role of membrane excitability in pancreatic β-cell glucotoxicity
por: Shyr, Zeenat A., et al.
Publicado: (2019)

Houttuynia cordata Thunb Promotes Activation of HIF-1A–FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells
por: Kim, Jung Min, et al.
Publicado: (2016)

Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
por: Katz, Liora S., et al.
Publicado: (2022)

Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway
por: Cui, Zhen Yang, et al.
Publicado: (2018)

Low glibenclamide concentrations affect endoplasmic reticulum stress in INS-1 cells under glucotoxic or glucolipotoxic conditions
por: Kwon, Min Jeong, et al.
Publicado: (2013)

Exendin-4 Protects Oxidative Stress-Induced β-Cell Apoptosis through Reduced JNK and GSK3β Activity
por: Kim, Ju-Young, et al.
Publicado: (2010)

HM-Chromanone Isolated from Portulaca Oleracea L. Protects INS-1 Pancreatic β Cells against Glucotoxicity-Induced Apoptosis
por: Park, Jae Eun, et al.
Publicado: (2019)

Undariopsis peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways
por: Kang, Jung-Il, et al.
Publicado: (2017)

Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells
por: Lee, Hae-Jung, et al.
Publicado: (2015)

Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure
por: Katz, Liora S., et al.
Publicado: (2022)

GSK3β Is Involved in JNK2-Mediated β-Catenin Inhibition
por: Hu, Dong, et al.
Publicado: (2009)

Testosterone Protects Pancreatic β-cells from Apoptosis and Stress-Induced Accelerated Senescence
por: Kang, Seon Mee, et al.
Publicado: (2021)

AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase
por: Jo, Daum, et al.
Publicado: (2018)

Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers
por: Hwang, Sung Min, et al.
Publicado: (2018)

Eucommia ulmoides Ameliorates Glucotoxicity by Suppressing Advanced Glycation End-Products in Diabetic Mice Kidney
por: Do, Moon Ho, et al.
Publicado: (2018)

DKK3, Downregulated in Invasive Epithelial Ovarian Cancer, Is Associated with Chemoresistance and Enhanced Paclitaxel Susceptibility via Inhibition of the β-Catenin-P-Glycoprotein Signaling Pathway
por: Nguyen, Que Thanh Thanh, et al.
Publicado: (2022)

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase
por: Namkoong, Sim, et al.
Publicado: (2015)

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
por: Jung, Youn-Sang, et al.
Publicado: (2015)

β-catenin induces expression of prohibitin gene in acute leukemic cells
por: Kim, Dong Min, et al.
Publicado: (2017)

Hepcidin as a key iron regulator mediates glucotoxicity-induced pancreatic β-cell dysfunction
por: Shu, Tingting, et al.
Publicado: (2019)

Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus
por: Ryu, Yeong Chan, et al.
Publicado: (2022)

Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
por: Kim, Hyun-Taek, et al.
Publicado: (2017)

FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
por: Kim, Kyoung Min, et al.
Publicado: (2019)

β-Lapachone Significantly Increases the Effect of Ionizing Radiation to Cause Mitochondrial Apoptosis via JNK Activation in Cancer Cells
por: Park, Moon-Taek, et al.
Publicado: (2011)

Niclosamide Inhibits Aortic Valve Interstitial Cell Calcification by Interfering with the GSK-3β/β-Catenin Signaling Pathway
por: Adhikari, Radhika, et al.
Publicado: (2023)

Overexpression of dopamine receptor D2 promotes colorectal cancer progression by activating the β‐catenin/ZEB1 axis
por: Lee, Hyunjung, et al.
Publicado: (2021)

The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces Autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation
por: Kang, Soouk, et al.
Publicado: (2014)

A Positive Tetraspanin 8 (TSPAN8)/β-Catenin Regulatory Loop Enhances the Stemness of Colorectal Cancer Cells
por: Zhan, Zhengyu, et al.
Publicado: (2019)

Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy
por: Do, Moon Ho, et al.
Publicado: (2019)

β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers
por: Kim, Won Kyu, et al.
Publicado: (2019)

Clinical Significance of Wnt/β-Catenin Signalling and Androgen Receptor Expression in Prostate Cancer
por: Jung, Soo Jin, et al.
Publicado: (2013)

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
por: Jung, Youn-Sang, et al.
Publicado: (2020)

Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells
por: Min, Hye-Jin, et al.
Publicado: (2009)

Ctbp2-mediated β-catenin regulation is required for exit from pluripotency
por: Kim, Tae Wan, et al.
Publicado: (2017)

β-catenin activates TGF-β-induced epithelial–mesenchymal transition in adenomyosis
por: Yoo, Jung-Yoon, et al.
Publicado: (2020)

Decursin and Decursinol Angelate Suppress Adipogenesis through Activation of β-catenin Signaling Pathway in Human Visceral Adipose-Derived Stem Cells
por: Park, In Sil, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p2i3q87429m5k9ntbimbfv4po0