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Rational engineering of the Neurospora VS ribozyme to allow substrate recognition via different kissing-loop interactions
The Neurospora VS ribozyme is a catalytic RNA that has the unique ability to specifically recognize and cleave a stem-loop substrate through formation of a highly stable kissing-loop interaction (KLI). In order to explore the engineering potential of the VS ribozyme to cleave alternate substrates, w...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001590/ https://www.ncbi.nlm.nih.gov/pubmed/27166370 http://dx.doi.org/10.1093/nar/gkw401 |