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The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O(6)-alkylguanine DNA adducts

Enzymatic approaches for locating alkylation adducts at single-base resolution in DNA could enable new technologies for understanding carcinogenesis and supporting personalized chemotherapy. Artificial nucleotides that specifically pair with alkylated bases offer a possible strategy for recognition...

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Detalles Bibliográficos
Autores principales:	Wyss, Laura A., Nilforoushan, Arman, Williams, David M., Marx, Andreas, Sturla, Shana J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001614/ https://www.ncbi.nlm.nih.gov/pubmed/27378785 http://dx.doi.org/10.1093/nar/gkw589

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