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Selectivity for strand-transfer over 3′-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme–DNA interactions in the active site
Integrase strand transfer inhibitors (INSTIs) are highly effective against HIV infections. Co-crystal structures of the prototype foamy virus intasome have shown that all three FDA-approved drugs, raltegravir (RAL), elvitegravir and dolutegravir (DTG), act as interfacial inhibitors during the strand...
Autores principales: | Métifiot, Mathieu, Johnson, Barry C., Kiselev, Evgeny, Marler, Laura, Zhao, Xue Zhi, Burke, Terrence R., Marchand, Christophe, Hughes, Stephen H., Pommier, Yves |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001616/ https://www.ncbi.nlm.nih.gov/pubmed/27369381 http://dx.doi.org/10.1093/nar/gkw592 |
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