Cargando…

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baradaran-Heravi, Alireza, Balgi, Aruna D., Zimmerman, Carla, Choi, Kunho, Shidmoossavee, Fahimeh S., Tan, Jason S., Bergeaud, Célia, Krause, Alexandra, Flibotte, Stéphane, Shimizu, Yoko, Anderson, Hilary J., Mouly, Vincent, Jan, Eric, Pfeifer, Tom, Jaquith, James B., Roberge, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001621/ https://www.ncbi.nlm.nih.gov/pubmed/27407112 http://dx.doi.org/10.1093/nar/gkw638

Ejemplares similares

Effect of small molecule eRF3 degraders on premature termination codon readthrough
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2021)

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough
por: Hosseini-Farahabadi, Sara, et al.
Publicado: (2021)

Nonselective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903
por: Baradaran-Heravi, Alireza, et al.
Publicado: (2022)

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
por: Frew, Jonathan, et al.
Publicado: (2020)

Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP
por: Lyu, Zhihui, et al.
Publicado: (2023)

The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418
por: Ferguson, Michael W., et al.
Publicado: (2019)

Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides
por: Wangen, Jamie R, et al.
Publicado: (2020)

Evaluation of Aminoglycoside and Non-Aminoglycoside Compounds for Stop-Codon Readthrough Therapy in Four Lysosomal Storage Diseases
por: Gómez-Grau, Marta, et al.
Publicado: (2015)

Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg(2+) ions
por: Zhang, Jingji, et al.
Publicado: (2018)

Modification of orthogonal tRNAs: unexpected consequences for sense codon reassignment
por: Biddle, Wil, et al.
Publicado: (2016)

Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria
por: Ling, Jiqiang, et al.
Publicado: (2014)

Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics
por: Savic, Miloje, et al.
Publicado: (2009)

Aminoglycoside-stimulated readthrough of premature termination codons in selected genes involved in primary ciliary dyskinesia
por: Bukowy-Bieryllo, Zuzanna, et al.
Publicado: (2016)

Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast
por: Chan, Clara S., et al.
Publicado: (2013)

HELZ2: a new, interferon-regulated, human 3′-5′ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon
por: Huntzinger, Eric, et al.
Publicado: (2023)

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations
por: Telwatte, Sushama, et al.
Publicado: (2015)

GO: a functional reporter system to identify and enrich base editing activity
por: Katti, Alyna, et al.
Publicado: (2020)

Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
por: Réblová, Kamila, et al.
Publicado: (2007)

Components of variance in transcriptomics based on electrophoretic separation of cDNA fragments (cDNA-AFLP)
por: Weiberg, Arne, et al.
Publicado: (2009)

RNA pseudoknots
por: Westhof, Eric, et al.
Publicado: (1992)

Isometric artifacts from polymerase chain reaction‐massively parallel sequencing analysis of short tandem repeat loci: An emerging issue from a new technology?
por: Zupanič Pajnič, Irena, et al.
Publicado: (2022)

Evolutionary Dynamics of Abundant Stop Codon Readthrough
por: Jungreis, Irwin, et al.
Publicado: (2016)

Completion of LINE integration involves an open ‘4-way’ branched DNA intermediate
por: Khadgi, Brijesh B, et al.
Publicado: (2019)

Endonuclease domain of non-LTR retrotransposons: loss-of-function mutants and modeling of the R2Bm endonuclease
por: Govindaraju, Aruna, et al.
Publicado: (2016)

CRISPR–Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells
por: Lin-Shiao, Enrique, et al.
Publicado: (2022)

Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough
por: Abreu, Renata B. V., et al.
Publicado: (2022)

Identification of stop codon readthrough genes in Saccharomyces cerevisiae
por: Namy, Olivier, et al.
Publicado: (2003)

Stop Codon Context-Specific Induction of Translational Readthrough
por: Schilff, Mirco, et al.
Publicado: (2021)

Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses
por: Núñez-Manchón, Estela, et al.
Publicado: (2021)

NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough
por: Omachi, Kohei, et al.
Publicado: (2022)

Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases
por: Guchhait, Sandip, et al.
Publicado: (2023)

The unfolded protein response affects readthrough of premature termination codons
por: Oren, Yifat S, et al.
Publicado: (2014)

Evidence of efficient stop codon readthrough in four mammalian genes
por: Loughran, Gary, et al.
Publicado: (2014)

Ataluren—Promising Therapeutic Premature Termination Codon Readthrough Frontrunner
por: Michorowska, Sylwia
Publicado: (2021)

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae
por: Mangkalaphiban, Kotchaphorn, et al.
Publicado: (2021)

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR
por: Smith, Emery, et al.
Publicado: (2020)

Pharmaceuticals Promoting Premature Termination Codon Readthrough: Progress in Development
por: Li, Shan, et al.
Publicado: (2023)

Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA
por: Price, Nathan E., et al.
Publicado: (2015)

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity
por: Prakash, Thazha P., et al.
Publicado: (2015)

Outwitting EF-Tu and the ribosome: translation with d-amino acids
por: Achenbach, John, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cr3f2ejqogl2ok6ip9j30u4vip