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Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record
Epilepsy is a prevalent chronic neurological disorder afflicting about 50 million people worldwide. There is evidence of a strong relationship between familial risk factors and epilepsy, as well as associations with substance use. The goal of this study was to explore the interactions between famili...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Medical Informatics Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001738/ https://www.ncbi.nlm.nih.gov/pubmed/27570679 |
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author | Wang, Yan Chen, Elizabeth S. Leppik, Ilo Pakhomov, Serguei Sarkar, Indra Neil Melton, Genevieve B. |
author_facet | Wang, Yan Chen, Elizabeth S. Leppik, Ilo Pakhomov, Serguei Sarkar, Indra Neil Melton, Genevieve B. |
author_sort | Wang, Yan |
collection | PubMed |
description | Epilepsy is a prevalent chronic neurological disorder afflicting about 50 million people worldwide. There is evidence of a strong relationship between familial risk factors and epilepsy, as well as associations with substance use. The goal of this study was to explore the interactions between familial risk factors and substance use based on structured data from the family and social history modules of an electronic health record system for adult epilepsy patients. A total of 8,957patients with 38,802 family history entries and 8,822 substance use entries were gathered and mined for associations at different levels of granularity for three age groupings (>18, 18-64, and ≥65 years old). Our results demonstrate the value of an association rule mining approach to validate knowledge of familial risk factors. The preliminary findings also suggest that substance use does not demonstrate significant association between social and familial risk factors for epilepsy. |
format | Online Article Text |
id | pubmed-5001738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | American Medical Informatics Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-50017382016-08-26 Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record Wang, Yan Chen, Elizabeth S. Leppik, Ilo Pakhomov, Serguei Sarkar, Indra Neil Melton, Genevieve B. AMIA Jt Summits Transl Sci Proc Articles Epilepsy is a prevalent chronic neurological disorder afflicting about 50 million people worldwide. There is evidence of a strong relationship between familial risk factors and epilepsy, as well as associations with substance use. The goal of this study was to explore the interactions between familial risk factors and substance use based on structured data from the family and social history modules of an electronic health record system for adult epilepsy patients. A total of 8,957patients with 38,802 family history entries and 8,822 substance use entries were gathered and mined for associations at different levels of granularity for three age groupings (>18, 18-64, and ≥65 years old). Our results demonstrate the value of an association rule mining approach to validate knowledge of familial risk factors. The preliminary findings also suggest that substance use does not demonstrate significant association between social and familial risk factors for epilepsy. American Medical Informatics Association 2016-07-20 /pmc/articles/PMC5001738/ /pubmed/27570679 Text en ©2016 AMIA - All rights reserved. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose |
spellingShingle | Articles Wang, Yan Chen, Elizabeth S. Leppik, Ilo Pakhomov, Serguei Sarkar, Indra Neil Melton, Genevieve B. Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record |
title | Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record |
title_full | Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record |
title_fullStr | Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record |
title_full_unstemmed | Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record |
title_short | Identifying Family History and Substance Use Associations for Adult Epilepsy from the Electronic Health Record |
title_sort | identifying family history and substance use associations for adult epilepsy from the electronic health record |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001738/ https://www.ncbi.nlm.nih.gov/pubmed/27570679 |
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