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How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?

Knowledge reuse of cancer trial designs may benefit from a temporal understanding of the evolution of the target populations of cancer studies over time. Therefore, we conducted a retrospective analysis of the trends of cancer trial eligibility criteria between 1999 and 2014. The yearly distribution...

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Detalles Bibliográficos
Autores principales: Yaman, Anil, Chakrabarti, Shreya, Sen, Anando, Weng, Chunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Informatics Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001741/
https://www.ncbi.nlm.nih.gov/pubmed/27570681
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author Yaman, Anil
Chakrabarti, Shreya
Sen, Anando
Weng, Chunhua
author_facet Yaman, Anil
Chakrabarti, Shreya
Sen, Anando
Weng, Chunhua
author_sort Yaman, Anil
collection PubMed
description Knowledge reuse of cancer trial designs may benefit from a temporal understanding of the evolution of the target populations of cancer studies over time. Therefore, we conducted a retrospective analysis of the trends of cancer trial eligibility criteria between 1999 and 2014. The yearly distributions of eligibility concepts for chemicals and drugs, procedures, observations, and medical conditions extracted from free-text eligibility criteria of 32,000 clinical trials for 89 cancer types were analyzed. We identified the concepts that trend upwards or downwards in all or selected cancer types, and the concepts that show anomalous trends for some cancers. Later, concept trends were studied in a disease-specific manner and illustrated for breast cancer. Criteria trends observed in this study are also validated and interpreted using evidence from the existing medical literature. This study contributes a method for concept trend analysis and original knowledge of the trends in cancer clinical trial eligibility criteria.
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spelling pubmed-50017412016-08-26 How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time? Yaman, Anil Chakrabarti, Shreya Sen, Anando Weng, Chunhua AMIA Jt Summits Transl Sci Proc Articles Knowledge reuse of cancer trial designs may benefit from a temporal understanding of the evolution of the target populations of cancer studies over time. Therefore, we conducted a retrospective analysis of the trends of cancer trial eligibility criteria between 1999 and 2014. The yearly distributions of eligibility concepts for chemicals and drugs, procedures, observations, and medical conditions extracted from free-text eligibility criteria of 32,000 clinical trials for 89 cancer types were analyzed. We identified the concepts that trend upwards or downwards in all or selected cancer types, and the concepts that show anomalous trends for some cancers. Later, concept trends were studied in a disease-specific manner and illustrated for breast cancer. Criteria trends observed in this study are also validated and interpreted using evidence from the existing medical literature. This study contributes a method for concept trend analysis and original knowledge of the trends in cancer clinical trial eligibility criteria. American Medical Informatics Association 2016-07-20 /pmc/articles/PMC5001741/ /pubmed/27570681 Text en ©2016 AMIA - All rights reserved. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose
spellingShingle Articles
Yaman, Anil
Chakrabarti, Shreya
Sen, Anando
Weng, Chunhua
How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?
title How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?
title_full How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?
title_fullStr How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?
title_full_unstemmed How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?
title_short How Have Cancer Clinical Trial Eligibility Criteria Evolved Over Time?
title_sort how have cancer clinical trial eligibility criteria evolved over time?
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001741/
https://www.ncbi.nlm.nih.gov/pubmed/27570681
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