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Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report

Patient: Female, 60 Final Diagnosis: Gastroesophageal carcinoma with rectal metastasis Symptoms: Bloating • constipation • weight loss Medication: — Clinical Procedure: Endoscopy • flexible sigmoidoscopy • lower endoscopic ultrasound Specialty: Gastroenterology and Hepatology OBJECTIVE: Unusual clin...

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Autores principales: Makker, Jasbir, Karki, Niraj, Sapkota, Binita, Niazi, Masooma, Remy, Prospere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001785/
https://www.ncbi.nlm.nih.gov/pubmed/27558656
http://dx.doi.org/10.12659/AJCR.898534
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author Makker, Jasbir
Karki, Niraj
Sapkota, Binita
Niazi, Masooma
Remy, Prospere
author_facet Makker, Jasbir
Karki, Niraj
Sapkota, Binita
Niazi, Masooma
Remy, Prospere
author_sort Makker, Jasbir
collection PubMed
description Patient: Female, 60 Final Diagnosis: Gastroesophageal carcinoma with rectal metastasis Symptoms: Bloating • constipation • weight loss Medication: — Clinical Procedure: Endoscopy • flexible sigmoidoscopy • lower endoscopic ultrasound Specialty: Gastroenterology and Hepatology OBJECTIVE: Unusual clinical course BACKGROUND: Gastroesophageal cancers, previously considered rare, are rapidly increasing worldwide. We present here a unique case of gastroesophageal carcinoma with metastasis to the rectum. CASE REPORT: A 60-year-old female patient presented with constipation, bloating, and weight loss of 4-month duration. She had undergone sleeve gastrectomy 6 years before. Endoscopies performed revealed a friable-looking mucosa in the lower esophagus and a polypoid rectal mass. Histopathological examination from both the esophageal and rectal lesions revealed poorly differentiated adenocarcinoma cells. Immunohistochemistry stain from both specimens was positive for CK7 supporting the gastric site primary with metastasis to the rectum. Further evaluation also revealed metastasis to bone and malignant pleural effusion. Chemotherapy with palliative intent was initiated. CONCLUSIONS: Colorectal metastasis is commonly seen from cancers of the breast, stomach, melanoma, kidney, prostate, and ovaries. However, colorectal metastasis from gastroesophageal cancer has never been reported in the medical literature. Diagnosis relies on histopathologic examination and immunohistochemical staining of the tumor. Treatment depends on the tumor stage. Tumors with widespread metastatic disease are candidates for palliative chemotherapy.
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spelling pubmed-50017852016-09-07 Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report Makker, Jasbir Karki, Niraj Sapkota, Binita Niazi, Masooma Remy, Prospere Am J Case Rep Articles Patient: Female, 60 Final Diagnosis: Gastroesophageal carcinoma with rectal metastasis Symptoms: Bloating • constipation • weight loss Medication: — Clinical Procedure: Endoscopy • flexible sigmoidoscopy • lower endoscopic ultrasound Specialty: Gastroenterology and Hepatology OBJECTIVE: Unusual clinical course BACKGROUND: Gastroesophageal cancers, previously considered rare, are rapidly increasing worldwide. We present here a unique case of gastroesophageal carcinoma with metastasis to the rectum. CASE REPORT: A 60-year-old female patient presented with constipation, bloating, and weight loss of 4-month duration. She had undergone sleeve gastrectomy 6 years before. Endoscopies performed revealed a friable-looking mucosa in the lower esophagus and a polypoid rectal mass. Histopathological examination from both the esophageal and rectal lesions revealed poorly differentiated adenocarcinoma cells. Immunohistochemistry stain from both specimens was positive for CK7 supporting the gastric site primary with metastasis to the rectum. Further evaluation also revealed metastasis to bone and malignant pleural effusion. Chemotherapy with palliative intent was initiated. CONCLUSIONS: Colorectal metastasis is commonly seen from cancers of the breast, stomach, melanoma, kidney, prostate, and ovaries. However, colorectal metastasis from gastroesophageal cancer has never been reported in the medical literature. Diagnosis relies on histopathologic examination and immunohistochemical staining of the tumor. Treatment depends on the tumor stage. Tumors with widespread metastatic disease are candidates for palliative chemotherapy. International Scientific Literature, Inc. 2016-08-25 /pmc/articles/PMC5001785/ /pubmed/27558656 http://dx.doi.org/10.12659/AJCR.898534 Text en © Am J Case Rep, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Articles
Makker, Jasbir
Karki, Niraj
Sapkota, Binita
Niazi, Masooma
Remy, Prospere
Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report
title Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report
title_full Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report
title_fullStr Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report
title_full_unstemmed Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report
title_short Rare Presentation of Gastroesophageal Carcinoma with Rectal Metastasis: A Case Report
title_sort rare presentation of gastroesophageal carcinoma with rectal metastasis: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001785/
https://www.ncbi.nlm.nih.gov/pubmed/27558656
http://dx.doi.org/10.12659/AJCR.898534
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