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Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism

OBJECTIVE: The optimal treatment of deep vein thrombosis (DVT) is anticoagulation therapy. Inferior vena cava filter (IVC) placement is another option for the prevention of pulmonary embolism (PE) in patients with deep vein thrombosis. This is used mostly in patients with a contraindication to antic...

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Autores principales: Zektser, Miri, Bartal, Carmi, Zeller, Lior, Nevzorov, Roman, Jotkowitz, Alan, Stavi, Vered, Romanyuk, Vitaly, Chudakov, Gregory, Barski, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rambam Health Care Campus 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001791/
https://www.ncbi.nlm.nih.gov/pubmed/27487310
http://dx.doi.org/10.5041/RMMJ.10246
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author Zektser, Miri
Bartal, Carmi
Zeller, Lior
Nevzorov, Roman
Jotkowitz, Alan
Stavi, Vered
Romanyuk, Vitaly
Chudakov, Gregory
Barski, Leonid
author_facet Zektser, Miri
Bartal, Carmi
Zeller, Lior
Nevzorov, Roman
Jotkowitz, Alan
Stavi, Vered
Romanyuk, Vitaly
Chudakov, Gregory
Barski, Leonid
author_sort Zektser, Miri
collection PubMed
description OBJECTIVE: The optimal treatment of deep vein thrombosis (DVT) is anticoagulation therapy. Inferior vena cava filter (IVC) placement is another option for the prevention of pulmonary embolism (PE) in patients with deep vein thrombosis. This is used mostly in patients with a contraindication to anticoagulant therapy. The purpose of the present study was to compare the two options. METHODS: A retrospective cohort study of two groups of patients with DVT: patients who received an IVC filter and did not receive anticoagulation due to contraindications; and patients with DVT and similar burden of comorbidity treated with anticoagulation without IVC insertion. To adjust for a potential misbalance in baseline characteristics between the two groups, we performed matching for age, gender, and Charlson’s index, which is used to compute the burden of comorbid conditions. The primary outcome was an occurrence of a PE. RESULTS: We studied 1,742 patients hospitalized with the diagnosis of DVT in our hospital;93 patients from this population received IVC filters. Charlson’s score index was significantly higher in the IVC filter group compared with the anticoagulation group. After matching of the groups of patients according to Charlson’s score index there were no significant differences in primary outcomes. CONCLUSION: Inferior vena cava filter without anticoagulation may be an alternative option for prevention of PE in patients with contraindications to anticoagulant therapy.
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spelling pubmed-50017912016-09-19 Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism Zektser, Miri Bartal, Carmi Zeller, Lior Nevzorov, Roman Jotkowitz, Alan Stavi, Vered Romanyuk, Vitaly Chudakov, Gregory Barski, Leonid Rambam Maimonides Med J Original Research OBJECTIVE: The optimal treatment of deep vein thrombosis (DVT) is anticoagulation therapy. Inferior vena cava filter (IVC) placement is another option for the prevention of pulmonary embolism (PE) in patients with deep vein thrombosis. This is used mostly in patients with a contraindication to anticoagulant therapy. The purpose of the present study was to compare the two options. METHODS: A retrospective cohort study of two groups of patients with DVT: patients who received an IVC filter and did not receive anticoagulation due to contraindications; and patients with DVT and similar burden of comorbidity treated with anticoagulation without IVC insertion. To adjust for a potential misbalance in baseline characteristics between the two groups, we performed matching for age, gender, and Charlson’s index, which is used to compute the burden of comorbid conditions. The primary outcome was an occurrence of a PE. RESULTS: We studied 1,742 patients hospitalized with the diagnosis of DVT in our hospital;93 patients from this population received IVC filters. Charlson’s score index was significantly higher in the IVC filter group compared with the anticoagulation group. After matching of the groups of patients according to Charlson’s score index there were no significant differences in primary outcomes. CONCLUSION: Inferior vena cava filter without anticoagulation may be an alternative option for prevention of PE in patients with contraindications to anticoagulant therapy. Rambam Health Care Campus 2016-07-28 /pmc/articles/PMC5001791/ /pubmed/27487310 http://dx.doi.org/10.5041/RMMJ.10246 Text en Copyright: © 2016 Zekster et al. This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Zektser, Miri
Bartal, Carmi
Zeller, Lior
Nevzorov, Roman
Jotkowitz, Alan
Stavi, Vered
Romanyuk, Vitaly
Chudakov, Gregory
Barski, Leonid
Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism
title Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism
title_full Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism
title_fullStr Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism
title_full_unstemmed Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism
title_short Effectiveness of Inferior Vena Cava Filters without Anticoagulation Therapy for Prophylaxis of Recurrent Pulmonary Embolism
title_sort effectiveness of inferior vena cava filters without anticoagulation therapy for prophylaxis of recurrent pulmonary embolism
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001791/
https://www.ncbi.nlm.nih.gov/pubmed/27487310
http://dx.doi.org/10.5041/RMMJ.10246
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