Cargando…

The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

In response to proteasome dysfunction, mammalian cells upregulate proteasome gene expression by activating Nrf1. Nrf1 is an endoplasmic reticulum-resident transcription factor that is continually retrotranslocated and degraded by the proteasome. Upon proteasome inhibition, Nrf1 escapes degradation a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koizumi, Shun, Irie, Taro, Hirayama, Shoshiro, Sakurai, Yasuyuki, Yashiroda, Hideki, Naguro, Isao, Ichijo, Hidenori, Hamazaki, Jun, Murata, Shigeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001836/ https://www.ncbi.nlm.nih.gov/pubmed/27528193 http://dx.doi.org/10.7554/eLife.18357

Ejemplares similares

The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma
por: Op, Mélanie, et al.
Publicado: (2022)

Sirt1-deficiency causes defective protein quality control
por: Tomita, Takuya, et al.
Publicado: (2015)

Enhanced O-GlcNAcylation Mediates Cytoprotection under Proteasome Impairment by Promoting Proteasome Turnover in Cancer Cells
por: Hashimoto, Eiichi, et al.
Publicado: (2020)

Transcriptional regulation of the 26S proteasome by Nrf1
por: KOIZUMI, Shun, et al.
Publicado: (2018)

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis
por: Hamazaki, Jun, et al.
Publicado: (2015)

Artemisinin Binds and Inhibits the Activity of Plasmodium falciparum Ddi1, a Retroviral Aspartyl Protease
por: Onchieku, Noah Machuki, et al.
Publicado: (2021)

ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond
por: Hamazaki, Jun, et al.
Publicado: (2020)

In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression
por: Kamiyama, Miki, et al.
Publicado: (2015)

NAMPT-dependent NAD(+) salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress
por: Nishida, Takuto, et al.
Publicado: (2022)

Recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2
por: Ibtisam, Ibtisam, et al.
Publicado: (2023)

The roles of ASK family proteins in stress responses and diseases
por: Hattori, Kazuki, et al.
Publicado: (2009)

The Molecular Mechanisms Governing the Assembly of the Immuno- and Thymoproteasomes in the Presence of Constitutive Proteasomes
por: Watanabe, Ayaka, et al.
Publicado: (2022)

KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation
por: Yamaguchi, Namiko, et al.
Publicado: (2016)

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
por: Lehrbach, Nicolas J, et al.
Publicado: (2016)

Disabling the Protease DDI2 Attenuates the Transcriptional Activity of NRF1 and Potentiates Proteasome Inhibitor Cytotoxicity
por: Northrop, Amy, et al.
Publicado: (2020)

Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival
por: Chen, Tianzeng, et al.
Publicado: (2022)

Assembly Mechanisms of Specialized Core Particles of the Proteasome
por: Bai, Minghui, et al.
Publicado: (2014)

Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system
por: Xu, Daichao, et al.
Publicado: (2015)

Complex DDI by Fenebrutinib and the Use of Transporter Endogenous Biomarkers to Elucidate the Mechanism of DDI
por: Jones, Nicholas S., et al.
Publicado: (2019)

ASK1 signalling regulates brown and beige adipocyte function
por: Hattori, Kazuki, et al.
Publicado: (2016)

Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway
por: Maruyama, Junichi, et al.
Publicado: (2016)

Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation
por: Ikizawa, Takeshi, et al.
Publicado: (2022)

A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases
por: Bradshaw, Niels, et al.
Publicado: (2017)

Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
por: Watanabe, Kengo, et al.
Publicado: (2021)

Anticoagulation in COVID-19: DDI Perspective
por: Khiali, Sajad, et al.
Publicado: (2020)

Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation
por: Marshall, Richard S, et al.
Publicado: (2018)

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress
por: Sekine, Shiori, et al.
Publicado: (2016)

ASK family kinases mediate cellular stress and redox signaling to circadian clock
por: Imamura, Kiyomichi, et al.
Publicado: (2018)

Retraction: Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation
por: Vierstra, Richard David
Publicado: (2022)

Nuclear export of ubiquitinated proteins via the UBIN-POST system
por: Hirayama, Shoshiro, et al.
Publicado: (2018)

Dynamic Regulation of Proteasome Expression
por: Motosugi, Ryo, et al.
Publicado: (2019)

Ddi1 is a ubiquitin-dependent protease
por: Yip, Matthew C. J., et al.
Publicado: (2020)

The protease DDI2 regulates NRF1 activation in response to cadmium toxicity
por: Ribeiro, Sérgio T., et al.
Publicado: (2022)

NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein
por: Waku, Tsuyoshi, et al.
Publicado: (2020)

Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation
por: Collins, Galen Andrew, et al.
Publicado: (2022)

Sex-specific adaptive homeostasis in D. melanogaster depends on increased proteolysis by the 20S Proteasome: Data-in-Brief
por: Pomatto, Laura C.D., et al.
Publicado: (2018)

Transfer of Ho Endonuclease and Ufo1 to the Proteasome by the UbL-UbA Shuttle Protein, Ddi1, Analysed by Complex Formation In Vitro
por: Voloshin, Olga, et al.
Publicado: (2012)

Addition of L-cysteine to the N- or C-terminus of the all-D-enantiomer [(D)(KLAKLAK)(2)] increases antimicrobial activities against multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli
por: Ohno, Maki K., et al.
Publicado: (2020)

RNA-dependent sterol aspartylation in fungi
por: Yakobov, Nathaniel, et al.
Publicado: (2020)

Signaling Functions of Intramembrane Aspartyl-Proteases
por: Papadopoulou, Alkmini A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gjb643en239a19rppt5hlgfudi