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Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review

BACKGROUND: The efficacy of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer’s disease (AD) has not been investigated. Therefore, we systematically reviewed the effect of TSG on cognitive deficits in a rodent model of AD. METHODS:...

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Autores principales: Sheng, Chenxia, Peng, Weijun, Chen, Zeqi, Cao, Yucheng, Gong, Wei, Xia, Zi-an, Wang, Yang, Su, Nanxiang, Wang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002158/
https://www.ncbi.nlm.nih.gov/pubmed/27565551
http://dx.doi.org/10.1186/s12906-016-1313-8
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author Sheng, Chenxia
Peng, Weijun
Chen, Zeqi
Cao, Yucheng
Gong, Wei
Xia, Zi-an
Wang, Yang
Su, Nanxiang
Wang, Zhe
author_facet Sheng, Chenxia
Peng, Weijun
Chen, Zeqi
Cao, Yucheng
Gong, Wei
Xia, Zi-an
Wang, Yang
Su, Nanxiang
Wang, Zhe
author_sort Sheng, Chenxia
collection PubMed
description BACKGROUND: The efficacy of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer’s disease (AD) has not been investigated. Therefore, we systematically reviewed the effect of TSG on cognitive deficits in a rodent model of AD. METHODS: We identified eligible studies published from January 1980 to April 2015 by searching seven electronic databases. We assessed the study quality, evaluated the efficacy of TSG treatment, and performed a stratified meta-analysis and meta-regression analysis to assess the influence of study design on TSG efficacy. RESULTS: Among a total of 381 publications, 18 fulfilled our inclusion criteria. The overall methodological quality of these studies was poor. The meta-analysis revealed a statistically significant benefit of TSG on acquisition memory (standardized mean difference [SMD] = −1.46 (95 % CI: −1.81 to −1.10, P < 0.0001) and retention memory (SMD =1.93 (95 % CI: 1.40 to 2.46, P < 0.0001) in experimental models of AD. The stratified analysis revealed a significantly higher effect size for both acquisition and retention memory in studies that used mixed sex models and a significantly higher effect size for acquisition memory in studies that used transgenic models. CONCLUSIONS: Our meta-analysis highlights a significantly better treatment effect in rodent AD models that received TSG that in those that did not. These findings indicate a potential therapeutic role of TSG in AD therapy. However, additional well-designed and detailed experimental studies are needed to evaluate the safety of TSG.
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spelling pubmed-50021582016-08-28 Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review Sheng, Chenxia Peng, Weijun Chen, Zeqi Cao, Yucheng Gong, Wei Xia, Zi-an Wang, Yang Su, Nanxiang Wang, Zhe BMC Complement Altern Med Research Article BACKGROUND: The efficacy of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer’s disease (AD) has not been investigated. Therefore, we systematically reviewed the effect of TSG on cognitive deficits in a rodent model of AD. METHODS: We identified eligible studies published from January 1980 to April 2015 by searching seven electronic databases. We assessed the study quality, evaluated the efficacy of TSG treatment, and performed a stratified meta-analysis and meta-regression analysis to assess the influence of study design on TSG efficacy. RESULTS: Among a total of 381 publications, 18 fulfilled our inclusion criteria. The overall methodological quality of these studies was poor. The meta-analysis revealed a statistically significant benefit of TSG on acquisition memory (standardized mean difference [SMD] = −1.46 (95 % CI: −1.81 to −1.10, P < 0.0001) and retention memory (SMD =1.93 (95 % CI: 1.40 to 2.46, P < 0.0001) in experimental models of AD. The stratified analysis revealed a significantly higher effect size for both acquisition and retention memory in studies that used mixed sex models and a significantly higher effect size for acquisition memory in studies that used transgenic models. CONCLUSIONS: Our meta-analysis highlights a significantly better treatment effect in rodent AD models that received TSG that in those that did not. These findings indicate a potential therapeutic role of TSG in AD therapy. However, additional well-designed and detailed experimental studies are needed to evaluate the safety of TSG. BioMed Central 2016-08-26 /pmc/articles/PMC5002158/ /pubmed/27565551 http://dx.doi.org/10.1186/s12906-016-1313-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Sheng, Chenxia
Peng, Weijun
Chen, Zeqi
Cao, Yucheng
Gong, Wei
Xia, Zi-an
Wang, Yang
Su, Nanxiang
Wang, Zhe
Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review
title Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review
title_full Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review
title_fullStr Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review
title_full_unstemmed Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review
title_short Impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside on cognitive deficits in animal models of Alzheimer’s disease: a systematic review
title_sort impact of 2, 3, 5, 4′-tetrahydroxystilbene-2-o-β-d-glucoside on cognitive deficits in animal models of alzheimer’s disease: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002158/
https://www.ncbi.nlm.nih.gov/pubmed/27565551
http://dx.doi.org/10.1186/s12906-016-1313-8
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