1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

BACKGROUND: Microglia, the immunocompetent cells of the CNS, rapidly respond to brain injury and disease by altering their morphology and phenotype to adopt an activated state. Microglia can exist broadly between two different states, namely the classical (M1) and the alternative (M2) phenotype. The...

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Detalles Bibliográficos
Autores principales: Plastira, Ioanna, Bernhart, Eva, Goeritzer, Madeleine, Reicher, Helga, Kumble, Vishwanath Bhat, Kogelnik, Nora, Wintersperger, Andrea, Hammer, Astrid, Schlager, Stefanie, Jandl, Katharina, Heinemann, Akos, Kratky, Dagmar, Malle, Ernst, Sattler, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002165/
https://www.ncbi.nlm.nih.gov/pubmed/27565558
http://dx.doi.org/10.1186/s12974-016-0701-9

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