Cargando…

An opportunistic study evaluating pharmacokinetics of sildenafil for the treatment of pulmonary hypertension in infants

OBJECTIVE: To assess sildenafil and N-desmethyl sildenafil (DMS) exposure in infants receiving sildenafil for the treatment of pulmonary hypertension (PH). STUDY DESIGN: Data were collected from 6 infants receiving sildenafil for the treatment of PH, and plasma samples were collected at the time of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thakkar, Nilay, Gonzalez, Daniel, Cohen-Wolkowiez, Michael, Massaro, Matthew, Bernhardt, Janice, Zane, Nicole R., Laughon, Matthew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002251/ https://www.ncbi.nlm.nih.gov/pubmed/27171763 http://dx.doi.org/10.1038/jp.2016.79

Ejemplares similares

Safety of sildenafil in extremely premature infants: a phase I trial
por: Jackson, Wesley, et al.
Publicado: (2021)

Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension
por: Rhee, Su-jin, et al.
Publicado: (2022)

Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil‐Bosentan and Sildenafil‐Ambrisentan Combination Therapies for Pulmonary Hypertension
por: Hakamata, A, et al.
Publicado: (2016)

Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants
por: Salerno, Sara N., et al.
Publicado: (2020)

Sildenafil and Retinopathy of Prematurity Risk in Very Low Birth Weight Infants
por: Samiee-Zafarghandy, Samira, et al.
Publicado: (2015)

Intravenous sildenafil for treatment of early pulmonary hypertension in preterm infants
por: Schroeder, Lukas, et al.
Publicado: (2023)

Efficacy of Sildenafil in Infants with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
por: Dillon, Kacie, et al.
Publicado: (2023)

Population Pharmacokinetics/Pharmacodynamics of 3,4‐Diaminopyridine Free Base in Patients With Lambert‐Eaton Myasthenia
por: Thakkar, Nilay, et al.
Publicado: (2017)

Sildenafil in the treatment of pulmonary hypertension
por: Barnett, Christopher F, et al.
Publicado: (2006)

Sildenafil in pediatric pulmonary arterial hypertension
por: Dhariwal, AK, et al.
Publicado: (2015)

Pharmacokinetics of single dose sildenafil orally administered in canine models of chronic embolic pulmonary hypertension
por: AKABANE, Ryota, et al.
Publicado: (2020)

Economic evaluation of sildenafil for the treatment of pulmonary arterial hypertension in Indonesia
por: Lilyasari, Oktavia, et al.
Publicado: (2019)

Safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia: Rationale and methods of a phase II randomized trial
por: Lang, Jason E., et al.
Publicado: (2022)

Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents
por: Ge, Shufan, et al.
Publicado: (2020)

Sildenafil in Infants and Children
por: Simonca, Larisa, et al.
Publicado: (2017)

Is Sildenafil an Effective Therapy in the Management of Persistent Pulmonary Hypertension?
por: Yaseen, Hakam, et al.
Publicado: (2012)

Bosentan and sildenafil in the treatment of HIV-associated pulmonary hypertension
por: Chinello, Pierangelo, et al.
Publicado: (2011)

Sildenafil in endotoxin-induced pulmonary hypertension: an experimental study
por: Kemper, Daniella Aparecida Godoi, et al.
Publicado: (2021)

Efficacy, safety and tolerability of bosentan as an adjuvant to sildenafil and sildenafil alone in persistant pulmonary hypertension of newborn (PPHN)
por: Vijay Kumar, J.R., et al.
Publicado: (2021)

Use of sildenafil in an infant with persistent pulmonary hypertension secondary to lung and renal hypoplasia – a case report
por: Lavie-Nevo, Karen, et al.
Publicado: (2019)

Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension
por: Toshner, Mark R., et al.
Publicado: (2010)

Safety of sildenafil in premature infants with severe bronchopulmonary dysplasia (SILDI-SAFE): a multicenter, randomized, placebo-controlled, sequential dose-escalating, double-masked, safety study
por: Schneider, Simone, et al.
Publicado: (2020)

Cefazolin Pharmacokinetics in Premature Infants
por: Balevic, Stephen J., et al.
Publicado: (2019)

Comparison of preventive effect of sildenafil and therapeutic effect of sildenafil treatment in rats with monocrotaline-induced pulmonary arterial hypertension
por: YOSHIYUKI, Rieko, et al.
Publicado: (2016)

Clinical deterioration after sildenafil cessation in patients with pulmonary hypertension
por: Keogh, Anne M, et al.
Publicado: (2008)

Simvastatin, Sildenafil and Their Combination in Monocrotaline Induced Pulmonary Arterial Hypertension
por: Lee, Dong Seok, et al.
Publicado: (2010)

Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension
por: Ramani, Gautam V, et al.
Publicado: (2010)

Reported Sildenafil Side Effects in Pediatric Pulmonary Hypertension Patients
por: Siehr, Stephanie L., et al.
Publicado: (2015)

Sildenafil for bronchopulmonary dysplasia and pulmonary hypertension: a meta-analysis
por: van der Graaf, Marisa, et al.
Publicado: (2019)

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond
por: Ghofrani, Hossein A., et al.
Publicado: (2006)

Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension
por: Tang, Yi, et al.
Publicado: (2022)

Current practices in the use of sildenafil for pulmonary arterial hypertension in Brazilian hospitals
por: de Souza, Ana HA, et al.
Publicado: (2009)

Intravenous sildenafil for postoperative pulmonary hypertension in children with congenital heart disease
por: Fraisse, Alain, et al.
Publicado: (2010)

Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension
por: Dodgen, Andrew L, et al.
Publicado: (2015)

Efficacy and safety of oral sildenafil in children with Down syndrome and pulmonary hypertension
por: Beghetti, Maurice, et al.
Publicado: (2017)

Efficacy of Sildenafil in Patients with Severe COVID-19 and Pulmonary Arterial Hypertension
por: Oliynyk, Oleksandr Valentynovych, et al.
Publicado: (2023)

The effects of sitaxentan on sildenafil pharmacokinetics and pharmacodynamics in healthy subjects
por: Stavros, Fiona, et al.
Publicado: (2010)

Changes in the Pharmacokinetics and Pharmacodynamics of Sildenafil in Cigarette and Cannabis Smokers
por: Murtadha, Mohammed, et al.
Publicado: (2021)

The hypertensive effect of sorafenib is abolished by sildenafil
por: Dabiré, Hubert, et al.
Publicado: (2020)

Lower Doses of Bosentan in Combination With Sildenafil Might be Beneficial in Pulmonary Arterial Hypertension
por: Amin, Ahmad, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ci8hrucp8p4itlqa3miqvc12na