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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators of M1-linked chains in vivo remains poorly understood. Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002269/ https://www.ncbi.nlm.nih.gov/pubmed/27523608 http://dx.doi.org/10.1016/j.cell.2016.07.019 |